In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturatio...

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Autores principales:	Jiying Ning, Gonca Erdemci-Tandogan, Ernest L. Yufenyuy, Jef Wagner, Benjamin A. Himes, Gongpu Zhao, Christopher Aiken, Roya Zandi, Peijun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6fb1da96d5249b4968508b5d2a47b9e
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spelling	oai:doaj.org-article:e6fb1da96d5249b4968508b5d2a47b9e2021-12-02T16:49:26ZIn vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway10.1038/ncomms136892041-1723https://doaj.org/article/e6fb1da96d5249b4968508b5d2a47b9e2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13689https://doaj.org/toc/2041-1723Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturation process.Jiying NingGonca Erdemci-TandoganErnest L. YufenyuyJef WagnerBenjamin A. HimesGongpu ZhaoChristopher AikenRoya ZandiPeijun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiying Ning Gonca Erdemci-Tandogan Ernest L. Yufenyuy Jef Wagner Benjamin A. Himes Gongpu Zhao Christopher Aiken Roya Zandi Peijun Zhang In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
description	Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturation process.
format	article
author	Jiying Ning Gonca Erdemci-Tandogan Ernest L. Yufenyuy Jef Wagner Benjamin A. Himes Gongpu Zhao Christopher Aiken Roya Zandi Peijun Zhang
author_facet	Jiying Ning Gonca Erdemci-Tandogan Ernest L. Yufenyuy Jef Wagner Benjamin A. Himes Gongpu Zhao Christopher Aiken Roya Zandi Peijun Zhang
author_sort	Jiying Ning
title	In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
title_short	In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
title_full	In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
title_fullStr	In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
title_full_unstemmed	In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
title_sort	in vitro protease cleavage and computer simulations reveal the hiv-1 capsid maturation pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e6fb1da96d5249b4968508b5d2a47b9e
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In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

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