Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds...

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Main Authors:	Antoni G. Wrobel, Donald J. Benton, Pengqi Xu, Lesley J. Calder, Annabel Borg, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb4
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spelling	oai:doaj.org-article:e6fc3e78a8f74f72b0f0a1e0880a8bb42021-12-02T14:06:22ZStructure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-210.1038/s41467-021-21006-92041-1723https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21006-9https://doaj.org/toc/2041-1723It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.Antoni G. WrobelDonald J. BentonPengqi XuLesley J. CalderAnnabel BorgChloë RoustanStephen R. MartinPeter B. RosenthalJohn J. SkehelSteven J. GamblinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antoni G. Wrobel Donald J. Benton Pengqi Xu Lesley J. Calder Annabel Borg Chloë Roustan Stephen R. Martin Peter B. Rosenthal John J. Skehel Steven J. Gamblin Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
description	It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.
format	article
author	Antoni G. Wrobel Donald J. Benton Pengqi Xu Lesley J. Calder Annabel Borg Chloë Roustan Stephen R. Martin Peter B. Rosenthal John J. Skehel Steven J. Gamblin
author_facet	Antoni G. Wrobel Donald J. Benton Pengqi Xu Lesley J. Calder Annabel Borg Chloë Roustan Stephen R. Martin Peter B. Rosenthal John J. Skehel Steven J. Gamblin
author_sort	Antoni G. Wrobel
title	Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
title_short	Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
title_full	Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
title_fullStr	Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
title_full_unstemmed	Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2
title_sort	structure and binding properties of pangolin-cov spike glycoprotein inform the evolution of sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb4
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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

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