An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

O’Donnell et al. describe their Tissue-Engineered Rostral Migratory Stream (TE-RMS) comprised of human astrocyte-like cells that can be derived from adult gingival stem cells within one week, which reorganizes into bundles of bidirectional, longitudinally-aligned astrocytes to emulate the endogenous...

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Autores principales:	John C. O’Donnell, Erin M. Purvis, Kaila V. T. Helm, Dayo O. Adewole, Qunzhou Zhang, Anh D. Le, D. Kacy Cullen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e6fc5006e1d74ab48e5a2c56d576f318
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spelling	oai:doaj.org-article:e6fc5006e1d74ab48e5a2c56d576f3182021-12-02T18:30:44ZAn implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement10.1038/s42003-021-02392-82399-3642https://doaj.org/article/e6fc5006e1d74ab48e5a2c56d576f3182021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02392-8https://doaj.org/toc/2399-3642O’Donnell et al. describe their Tissue-Engineered Rostral Migratory Stream (TE-RMS) comprised of human astrocyte-like cells that can be derived from adult gingival stem cells within one week, which reorganizes into bundles of bidirectional, longitudinally-aligned astrocytes to emulate the endogenous RMS. Establishing immature neuronal migration in vitro and in vivo, their study demonstrates surgical feasibility and proof-of-concept evidence for this nascent technology.John C. O’DonnellErin M. PurvisKaila V. T. HelmDayo O. AdewoleQunzhou ZhangAnh D. LeD. Kacy CullenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 John C. O’Donnell Erin M. Purvis Kaila V. T. Helm Dayo O. Adewole Qunzhou Zhang Anh D. Le D. Kacy Cullen An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
description	O’Donnell et al. describe their Tissue-Engineered Rostral Migratory Stream (TE-RMS) comprised of human astrocyte-like cells that can be derived from adult gingival stem cells within one week, which reorganizes into bundles of bidirectional, longitudinally-aligned astrocytes to emulate the endogenous RMS. Establishing immature neuronal migration in vitro and in vivo, their study demonstrates surgical feasibility and proof-of-concept evidence for this nascent technology.
format	article
author	John C. O’Donnell Erin M. Purvis Kaila V. T. Helm Dayo O. Adewole Qunzhou Zhang Anh D. Le D. Kacy Cullen
author_facet	John C. O’Donnell Erin M. Purvis Kaila V. T. Helm Dayo O. Adewole Qunzhou Zhang Anh D. Le D. Kacy Cullen
author_sort	John C. O’Donnell
title	An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
title_short	An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
title_full	An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
title_fullStr	An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
title_full_unstemmed	An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
title_sort	implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6fc5006e1d74ab48e5a2c56d576f318
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An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

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