The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil

In Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium...

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Autores principales:	Lucio Milillo, Fabrizio Cinone, Federico Lo Presti, Dorina Lauritano, Massimo Petruzzi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	blood clot titanium foil bone augmentation guided bone regeneration Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/e6ff38a4972a45dbb8b1577f00fdbb59
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spelling	oai:doaj.org-article:e6ff38a4972a45dbb8b1577f00fdbb592021-11-11T18:09:58ZThe Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil10.3390/ma142166421996-1944https://doaj.org/article/e6ff38a4972a45dbb8b1577f00fdbb592021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6642https://doaj.org/toc/1996-1944In Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium foil, as it can be shaped according to the bone defect. Furthermore, its exposition in the oral cavity does not impair the procedure. We report on five clinical cases in order to explain the management of blood clots in combination with titanium foil barriers in different clinical settings. Besides being the best choice to protect the clot, the titanium foil represents an excellent barrier that is useful in GBR due to its biocompatibility, handling, and mechanical strength properties. The clot alone is the best natural scaffold to obtain the ideal bone quality and avoid the persistence of not-resorbed granules of filler materials in the newly regenerated bone. Even though clot contraction still needs to be improved, as it impacts the volume of the regenerated bone, future studies in GBR should be inspired by the clot and its fundamental properties.Lucio MililloFabrizio CinoneFederico Lo PrestiDorina LauritanoMassimo PetruzziMDPI AGarticleblood clottitanium foilbone augmentationguided bone regenerationTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6642, p 6642 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood clot titanium foil bone augmentation guided bone regeneration Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	blood clot titanium foil bone augmentation guided bone regeneration Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Lucio Milillo Fabrizio Cinone Federico Lo Presti Dorina Lauritano Massimo Petruzzi The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
description	In Guided Bone Regeneration (GBR) materials and techniques are essential to achieve the expected results. Thanks to their properties, blood clots induce bone healing, maturation, differentiation and organization. The preferred material to protect the clot in Guided Bone Regeneration is the titanium foil, as it can be shaped according to the bone defect. Furthermore, its exposition in the oral cavity does not impair the procedure. We report on five clinical cases in order to explain the management of blood clots in combination with titanium foil barriers in different clinical settings. Besides being the best choice to protect the clot, the titanium foil represents an excellent barrier that is useful in GBR due to its biocompatibility, handling, and mechanical strength properties. The clot alone is the best natural scaffold to obtain the ideal bone quality and avoid the persistence of not-resorbed granules of filler materials in the newly regenerated bone. Even though clot contraction still needs to be improved, as it impacts the volume of the regenerated bone, future studies in GBR should be inspired by the clot and its fundamental properties.
format	article
author	Lucio Milillo Fabrizio Cinone Federico Lo Presti Dorina Lauritano Massimo Petruzzi
author_facet	Lucio Milillo Fabrizio Cinone Federico Lo Presti Dorina Lauritano Massimo Petruzzi
author_sort	Lucio Milillo
title	The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
title_short	The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
title_full	The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
title_fullStr	The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
title_full_unstemmed	The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil
title_sort	role of blood clot in guided bone regeneration: biological considerations and clinical applications with titanium foil
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e6ff38a4972a45dbb8b1577f00fdbb59
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The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil

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