Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig

Abstract The purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs’ eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was control...

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Autores principales:	Mihyun Choi, Seong-Woo Kim, Somin Ahn, Thi Que Anh Vu, Cheolmin Yun, Yong Yeon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6ff441ac7144976b9c84bd2f53c01e3
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spelling	oai:doaj.org-article:e6ff441ac7144976b9c84bd2f53c01e32021-12-02T13:39:23ZRelationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig10.1038/s41598-021-87689-82045-2322https://doaj.org/article/e6ff441ac7144976b9c84bd2f53c01e32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87689-8https://doaj.org/toc/2045-2322Abstract The purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs’ eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was controlled from 15 mmHg (baseline) to 105 mmHg in 15 mmHg increments using a vented-gas forced-infusion system, and then decreased back to normal IOP (recovery state). The spectral-domain OCTA device was set to scan an area of 8.8 × 4.4 mm (30° × 15°) above the optic nerve head for each IOP. The relative vessel density (rVAD) compared to baseline was determined for the total retinal blood flow (RBF) which included major retinal artery and venous vessels, radial peripapillary capillaries (RPCs), superficial (SVP), intermediate (IVP), and deep vascular plexus (DVP). The mean rVAD was 0.890 in RBF, 0.826 in RPCs, 0.817 in SVP, 0.819 in IVP, and 0.794 in DVP at 30 mmHg. While the rVAD of RBF and RPCs decreased to 0.504 and 0.541 at 45 mmHg, the SVP, IVP, and DVP decreased to 0.433, 0.359, and 0.345, respectively. When IOP was normalized, the rVAD was recovered in all layers and the VAD of RBF, IVP, and DVP were higher than baseline (P = 0.040, 0.019, and 0.019, respectively). Retinal capillary density deterioration in each layer was found from 30 mmHg using an OCTA system which showed excellent depth-resolved segmentation of retinal capillary layers even at higher IOPs. Reduction in VAD showed full recovery after IOP normalization.Mihyun ChoiSeong-Woo KimSomin AhnThi Que Anh VuCheolmin YunYong Yeon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mihyun Choi Seong-Woo Kim Somin Ahn Thi Que Anh Vu Cheolmin Yun Yong Yeon Kim Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
description	Abstract The purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs’ eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was controlled from 15 mmHg (baseline) to 105 mmHg in 15 mmHg increments using a vented-gas forced-infusion system, and then decreased back to normal IOP (recovery state). The spectral-domain OCTA device was set to scan an area of 8.8 × 4.4 mm (30° × 15°) above the optic nerve head for each IOP. The relative vessel density (rVAD) compared to baseline was determined for the total retinal blood flow (RBF) which included major retinal artery and venous vessels, radial peripapillary capillaries (RPCs), superficial (SVP), intermediate (IVP), and deep vascular plexus (DVP). The mean rVAD was 0.890 in RBF, 0.826 in RPCs, 0.817 in SVP, 0.819 in IVP, and 0.794 in DVP at 30 mmHg. While the rVAD of RBF and RPCs decreased to 0.504 and 0.541 at 45 mmHg, the SVP, IVP, and DVP decreased to 0.433, 0.359, and 0.345, respectively. When IOP was normalized, the rVAD was recovered in all layers and the VAD of RBF, IVP, and DVP were higher than baseline (P = 0.040, 0.019, and 0.019, respectively). Retinal capillary density deterioration in each layer was found from 30 mmHg using an OCTA system which showed excellent depth-resolved segmentation of retinal capillary layers even at higher IOPs. Reduction in VAD showed full recovery after IOP normalization.
format	article
author	Mihyun Choi Seong-Woo Kim Somin Ahn Thi Que Anh Vu Cheolmin Yun Yong Yeon Kim
author_facet	Mihyun Choi Seong-Woo Kim Somin Ahn Thi Que Anh Vu Cheolmin Yun Yong Yeon Kim
author_sort	Mihyun Choi
title	Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
title_short	Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
title_full	Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
title_fullStr	Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
title_full_unstemmed	Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig
title_sort	relationship between retinal capillary vessel density of oct angiography and intraocular pressure in pig
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6ff441ac7144976b9c84bd2f53c01e3
work_keys_str_mv	AT mihyunchoi relationshipbetweenretinalcapillaryvesseldensityofoctangiographyandintraocularpressureinpig AT seongwookim relationshipbetweenretinalcapillaryvesseldensityofoctangiographyandintraocularpressureinpig AT sominahn relationshipbetweenretinalcapillaryvesseldensityofoctangiographyandintraocularpressureinpig AT thiqueanhvu relationshipbetweenretinalcapillaryvesseldensityofoctangiographyandintraocularpressureinpig AT cheolminyun relationshipbetweenretinalcapillaryvesseldensityofoctangiographyandintraocularpressureinpig AT yongyeonkim relationshipbetweenretinalcapillaryvesseldensityofoctangiographyandintraocularpressureinpig
_version_	1718392649889611776

Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig

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