Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin

Abstract Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has been used as a non-invasive and label-free...

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Autores principales:	Katsuhiko Tsuchida, Masaki Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7000b2c6d2f489dad4b5375726033a1
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spelling	oai:doaj.org-article:e7000b2c6d2f489dad4b5375726033a12021-12-02T12:33:06ZUltraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin10.1038/s41598-020-78884-02045-2322https://doaj.org/article/e7000b2c6d2f489dad4b5375726033a12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78884-0https://doaj.org/toc/2045-2322Abstract Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has been used as a non-invasive and label-free marker for the evaluation of oxidative stress. However, the mechanism of UPE generation is not clear. Therefore, we aimed to elucidate the molecular mechanism underlying UPE generation by analyzing the spectra of UPE generated from biomolecules in the skin during ultraviolet A (UVA) exposure. The spectra of UVA-induced UPE generated from linoleic acid, linolenic acid, elastin, phospholipids, and 5,6-dihydroxyindole-2-carboxylic acid were measured, and the spectrum of human skin tissue was also obtained. The spectral patterns varied for the different biomolecules and the peaks were distinct from those of the skin tissue. These results suggested that the UPE generated from skin tissue is a collection of light emitted by biomolecules. Moreover, we proposed that UPE is generated through a photosensitization reaction and energy transfer. The identified characteristic spectral patterns of UPE can be useful to elucidate UVA-induced oxidative stress in the skin, with implications for prevention and treatment of photoaging and skin diseases.Katsuhiko TsuchidaMasaki KobayashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katsuhiko Tsuchida Masaki Kobayashi Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
description	Abstract Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has been used as a non-invasive and label-free marker for the evaluation of oxidative stress. However, the mechanism of UPE generation is not clear. Therefore, we aimed to elucidate the molecular mechanism underlying UPE generation by analyzing the spectra of UPE generated from biomolecules in the skin during ultraviolet A (UVA) exposure. The spectra of UVA-induced UPE generated from linoleic acid, linolenic acid, elastin, phospholipids, and 5,6-dihydroxyindole-2-carboxylic acid were measured, and the spectrum of human skin tissue was also obtained. The spectral patterns varied for the different biomolecules and the peaks were distinct from those of the skin tissue. These results suggested that the UPE generated from skin tissue is a collection of light emitted by biomolecules. Moreover, we proposed that UPE is generated through a photosensitization reaction and energy transfer. The identified characteristic spectral patterns of UPE can be useful to elucidate UVA-induced oxidative stress in the skin, with implications for prevention and treatment of photoaging and skin diseases.
format	article
author	Katsuhiko Tsuchida Masaki Kobayashi
author_facet	Katsuhiko Tsuchida Masaki Kobayashi
author_sort	Katsuhiko Tsuchida
title	Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
title_short	Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
title_full	Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
title_fullStr	Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
title_full_unstemmed	Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
title_sort	ultraviolet a irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e7000b2c6d2f489dad4b5375726033a1
work_keys_str_mv	AT katsuhikotsuchida ultravioletairradiationinducesultraweakphotonemissionwithcharacteristicspectralpatternsfrombiomoleculespresentinhumanskin AT masakikobayashi ultravioletairradiationinducesultraweakphotonemissionwithcharacteristicspectralpatternsfrombiomoleculespresentinhumanskin
_version_	1718393892143890432

Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin

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