Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells

This study shows that efflux is important for maintaining low intracellular accumulation only in actively growing cells and that envelope permeability is the predominant factor in stationary-phase cells. This conclusion means that (i) antibiotics with intracellular targets may be less effective in...

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Autores principales:	Emily E. Whittle, Helen E. McNeil, Eleftheria Trampari, Mark Webber, Tim W. Overton, Jessica M. A. Blair
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e7078d590ca34faf877a261e8fd24c0f
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spelling	oai:doaj.org-article:e7078d590ca34faf877a261e8fd24c0f2021-11-03T21:52:35ZEfflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells2150-751110.1128/mBio.02608-21https://doaj.org/article/e7078d590ca34faf877a261e8fd24c0f2021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02608-21https://doaj.org/toc/2150-7511 This study shows that efflux is important for maintaining low intracellular accumulation only in actively growing cells and that envelope permeability is the predominant factor in stationary-phase cells. This conclusion means that (i) antibiotics with intracellular targets may be less effective in complex infections with nongrowing or slow-growing bacteria, where intracellular accumulation may be low; (ii) efflux inhibitors may be successful in potentiating the activity of existing antibiotics, but potentially only for bacterial infections where cells are actively growing; and (iii) the remodeling of the cell envelope prior to stationary phase could provide novel drug targets.Emily E. WhittleHelen E. McNeilEleftheria TrampariMark WebberTim W. OvertonJessica M. A. BlairAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Emily E. Whittle Helen E. McNeil Eleftheria Trampari Mark Webber Tim W. Overton Jessica M. A. Blair Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells
description	This study shows that efflux is important for maintaining low intracellular accumulation only in actively growing cells and that envelope permeability is the predominant factor in stationary-phase cells. This conclusion means that (i) antibiotics with intracellular targets may be less effective in complex infections with nongrowing or slow-growing bacteria, where intracellular accumulation may be low; (ii) efflux inhibitors may be successful in potentiating the activity of existing antibiotics, but potentially only for bacterial infections where cells are actively growing; and (iii) the remodeling of the cell envelope prior to stationary phase could provide novel drug targets.
format	article
author	Emily E. Whittle Helen E. McNeil Eleftheria Trampari Mark Webber Tim W. Overton Jessica M. A. Blair
author_facet	Emily E. Whittle Helen E. McNeil Eleftheria Trampari Mark Webber Tim W. Overton Jessica M. A. Blair
author_sort	Emily E. Whittle
title	Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells
title_short	Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells
title_full	Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells
title_fullStr	Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells
title_full_unstemmed	Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells
title_sort	efflux impacts intracellular accumulation only in actively growing bacterial cells
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/e7078d590ca34faf877a261e8fd24c0f
work_keys_str_mv	AT emilyewhittle effluximpactsintracellularaccumulationonlyinactivelygrowingbacterialcells AT helenemcneil effluximpactsintracellularaccumulationonlyinactivelygrowingbacterialcells AT eleftheriatrampari effluximpactsintracellularaccumulationonlyinactivelygrowingbacterialcells AT markwebber effluximpactsintracellularaccumulationonlyinactivelygrowingbacterialcells AT timwoverton effluximpactsintracellularaccumulationonlyinactivelygrowingbacterialcells AT jessicamablair effluximpactsintracellularaccumulationonlyinactivelygrowingbacterialcells
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Efflux Impacts Intracellular Accumulation Only in Actively Growing Bacterial Cells

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