PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure.
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Nature Portfolio
2018
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oai:doaj.org-article:e70a2475a25a49f6b0fbaaaa812f41c82021-12-02T17:32:14ZPI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease10.1038/s41467-018-07812-82041-1723https://doaj.org/article/e70a2475a25a49f6b0fbaaaa812f41c82018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07812-8https://doaj.org/toc/2041-1723Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure.Vaibhav B. PatelPavel ZhabyeyevXueyi ChenFaqi WangManish PaulDong FanBrent A. McLeanRatnadeep BasuPu ZhangSaumya ShahJohn F. DawsonW. Glen PyleMousumi HazraZamaneh KassiriSaugata HazraBart VanhaesebroeckChristopher A. McCullochGavin Y. OuditNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Vaibhav B. Patel Pavel Zhabyeyev Xueyi Chen Faqi Wang Manish Paul Dong Fan Brent A. McLean Ratnadeep Basu Pu Zhang Saumya Shah John F. Dawson W. Glen Pyle Mousumi Hazra Zamaneh Kassiri Saugata Hazra Bart Vanhaesebroeck Christopher A. McCulloch Gavin Y. Oudit PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| description |
Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure. |
| format |
article |
| author |
Vaibhav B. Patel Pavel Zhabyeyev Xueyi Chen Faqi Wang Manish Paul Dong Fan Brent A. McLean Ratnadeep Basu Pu Zhang Saumya Shah John F. Dawson W. Glen Pyle Mousumi Hazra Zamaneh Kassiri Saugata Hazra Bart Vanhaesebroeck Christopher A. McCulloch Gavin Y. Oudit |
| author_facet |
Vaibhav B. Patel Pavel Zhabyeyev Xueyi Chen Faqi Wang Manish Paul Dong Fan Brent A. McLean Ratnadeep Basu Pu Zhang Saumya Shah John F. Dawson W. Glen Pyle Mousumi Hazra Zamaneh Kassiri Saugata Hazra Bart Vanhaesebroeck Christopher A. McCulloch Gavin Y. Oudit |
| author_sort |
Vaibhav B. Patel |
| title |
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| title_short |
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| title_full |
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| title_fullStr |
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| title_full_unstemmed |
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| title_sort |
pi3kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e70a2475a25a49f6b0fbaaaa812f41c8 |
| work_keys_str_mv |
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