The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
The oncolytic virus Delta-24-RGD is in clinical trial for adult glioma. Here, the authors show that this virus elicits an immune response in mouse models of pediatric high-grade glioma and diffuse pontine intrinsic glioma, resulting in improved survival.
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Nature Portfolio
2019
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oai:doaj.org-article:e70b68b3d2c14bafb5f5185c1fba26c62021-12-02T17:01:46ZThe oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models10.1038/s41467-019-10043-02041-1723https://doaj.org/article/e70b68b3d2c14bafb5f5185c1fba26c62019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10043-0https://doaj.org/toc/2041-1723The oncolytic virus Delta-24-RGD is in clinical trial for adult glioma. Here, the authors show that this virus elicits an immune response in mouse models of pediatric high-grade glioma and diffuse pontine intrinsic glioma, resulting in improved survival.Naiara Martínez-VélezMarc Garcia-MoureMiguel MarigilMarisol González-HuarrizMontse PuigdellosesJaime Gallego Pérez-LarrayaMarta ZalacaínLucía MarrodánMaider Varela-GuruceagaVirginia LaspideaJose Javier AristuLuis Isaac RamosSonia Tejada-SolísRicardo Díez-ValleChris JonesAlan MackayJose A. Martínez-ClimentMaria Jose García-BarchinoEric RaabeMichelle MonjeOren J. BecherMarie Pierre JunierElias A. El-HabrHerve ChneiweissGuillermo AldaveHong JiangJuan FueyoAna Patiño-GarcíaCandelaria Gomez-ManzanoMarta M. AlonsoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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Science Q Naiara Martínez-Vélez Marc Garcia-Moure Miguel Marigil Marisol González-Huarriz Montse Puigdelloses Jaime Gallego Pérez-Larraya Marta Zalacaín Lucía Marrodán Maider Varela-Guruceaga Virginia Laspidea Jose Javier Aristu Luis Isaac Ramos Sonia Tejada-Solís Ricardo Díez-Valle Chris Jones Alan Mackay Jose A. Martínez-Climent Maria Jose García-Barchino Eric Raabe Michelle Monje Oren J. Becher Marie Pierre Junier Elias A. El-Habr Herve Chneiweiss Guillermo Aldave Hong Jiang Juan Fueyo Ana Patiño-García Candelaria Gomez-Manzano Marta M. Alonso The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models |
| description |
The oncolytic virus Delta-24-RGD is in clinical trial for adult glioma. Here, the authors show that this virus elicits an immune response in mouse models of pediatric high-grade glioma and diffuse pontine intrinsic glioma, resulting in improved survival. |
| format |
article |
| author |
Naiara Martínez-Vélez Marc Garcia-Moure Miguel Marigil Marisol González-Huarriz Montse Puigdelloses Jaime Gallego Pérez-Larraya Marta Zalacaín Lucía Marrodán Maider Varela-Guruceaga Virginia Laspidea Jose Javier Aristu Luis Isaac Ramos Sonia Tejada-Solís Ricardo Díez-Valle Chris Jones Alan Mackay Jose A. Martínez-Climent Maria Jose García-Barchino Eric Raabe Michelle Monje Oren J. Becher Marie Pierre Junier Elias A. El-Habr Herve Chneiweiss Guillermo Aldave Hong Jiang Juan Fueyo Ana Patiño-García Candelaria Gomez-Manzano Marta M. Alonso |
| author_facet |
Naiara Martínez-Vélez Marc Garcia-Moure Miguel Marigil Marisol González-Huarriz Montse Puigdelloses Jaime Gallego Pérez-Larraya Marta Zalacaín Lucía Marrodán Maider Varela-Guruceaga Virginia Laspidea Jose Javier Aristu Luis Isaac Ramos Sonia Tejada-Solís Ricardo Díez-Valle Chris Jones Alan Mackay Jose A. Martínez-Climent Maria Jose García-Barchino Eric Raabe Michelle Monje Oren J. Becher Marie Pierre Junier Elias A. El-Habr Herve Chneiweiss Guillermo Aldave Hong Jiang Juan Fueyo Ana Patiño-García Candelaria Gomez-Manzano Marta M. Alonso |
| author_sort |
Naiara Martínez-Vélez |
| title |
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models |
| title_short |
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models |
| title_full |
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models |
| title_fullStr |
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models |
| title_full_unstemmed |
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models |
| title_sort |
oncolytic virus delta-24-rgd elicits an antitumor effect in pediatric glioma and dipg mouse models |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/e70b68b3d2c14bafb5f5185c1fba26c6 |
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