Ternary Ti alloys functionalised with antibacterial activity

Abstract Prosthesis bacterial infection occurring during surgery is a rising health issue. Pathogenic bacterial infection causes inflammation, interferes with the healing process, inhibits osteogenesis and, eventually, leads to implant failure. These issues can be tackled either by applying coatings...

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Autores principales:	L. Bolzoni, M. Alqattan, L. Peters, Y. Alshammari, F. Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e70cb8d4995d4998bc6a55e33de3ae84
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spelling	oai:doaj.org-article:e70cb8d4995d4998bc6a55e33de3ae842021-12-02T12:03:16ZTernary Ti alloys functionalised with antibacterial activity10.1038/s41598-020-79192-32045-2322https://doaj.org/article/e70cb8d4995d4998bc6a55e33de3ae842020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79192-3https://doaj.org/toc/2045-2322Abstract Prosthesis bacterial infection occurring during surgery is a rising health issue. Pathogenic bacterial infection causes inflammation, interferes with the healing process, inhibits osteogenesis and, eventually, leads to implant failure. These issues can be tackled either by applying coatings or developing multifunctional (i.e. structural and antibacterial) materials. In this work, β eutectoid bearing functionalised Ti alloys were designed and manufactured via the cost-effective press and sinter powder metallurgy route. The systematic analysis of the ternary Ti–xCu–yMn alloys shows that the mechanical properties proportionally increase with the amount of alloying elements added. All the ternary Ti–xCu–yMn alloys have strong antibacterial activity against Escherichia coli with respect to the negative control (i.e. pure Ti). Our study demonstrates that ternary Ti–xCu–yMn alloys are promising candidates for structural prostheses functionalised with antibacterial capability.L. BolzoniM. AlqattanL. PetersY. AlshammariF. YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. Bolzoni M. Alqattan L. Peters Y. Alshammari F. Yang Ternary Ti alloys functionalised with antibacterial activity
description	Abstract Prosthesis bacterial infection occurring during surgery is a rising health issue. Pathogenic bacterial infection causes inflammation, interferes with the healing process, inhibits osteogenesis and, eventually, leads to implant failure. These issues can be tackled either by applying coatings or developing multifunctional (i.e. structural and antibacterial) materials. In this work, β eutectoid bearing functionalised Ti alloys were designed and manufactured via the cost-effective press and sinter powder metallurgy route. The systematic analysis of the ternary Ti–xCu–yMn alloys shows that the mechanical properties proportionally increase with the amount of alloying elements added. All the ternary Ti–xCu–yMn alloys have strong antibacterial activity against Escherichia coli with respect to the negative control (i.e. pure Ti). Our study demonstrates that ternary Ti–xCu–yMn alloys are promising candidates for structural prostheses functionalised with antibacterial capability.
format	article
author	L. Bolzoni M. Alqattan L. Peters Y. Alshammari F. Yang
author_facet	L. Bolzoni M. Alqattan L. Peters Y. Alshammari F. Yang
author_sort	L. Bolzoni
title	Ternary Ti alloys functionalised with antibacterial activity
title_short	Ternary Ti alloys functionalised with antibacterial activity
title_full	Ternary Ti alloys functionalised with antibacterial activity
title_fullStr	Ternary Ti alloys functionalised with antibacterial activity
title_full_unstemmed	Ternary Ti alloys functionalised with antibacterial activity
title_sort	ternary ti alloys functionalised with antibacterial activity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e70cb8d4995d4998bc6a55e33de3ae84
work_keys_str_mv	AT lbolzoni ternarytialloysfunctionalisedwithantibacterialactivity AT malqattan ternarytialloysfunctionalisedwithantibacterialactivity AT lpeters ternarytialloysfunctionalisedwithantibacterialactivity AT yalshammari ternarytialloysfunctionalisedwithantibacterialactivity AT fyang ternarytialloysfunctionalisedwithantibacterialactivity
_version_	1718394781109846016

Ternary Ti alloys functionalised with antibacterial activity

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