MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

MLL5 is an essential epigenetic modifier involved in cell cycle progression, chromatin architecture and hematopoiesis. Here the authors establish that MLL5 suppresses the innate immune response in a murine model of virus infection by targeting and promoting degradation of RIG-I.

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Autores principales: Peipei Zhou, Xiaodan Ding, Xiaoling Wan, Lulu Liu, Xiujie Yuan, Wei Zhang, Xinhui Hui, Guangxun Meng, Hui Xiao, Bin Li, Jin Zhong, Fajian Hou, Lihwen Deng, Yan Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e70d4a2c123b46d1aff993ffe9991d7e
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spelling oai:doaj.org-article:e70d4a2c123b46d1aff993ffe9991d7e2021-12-02T13:27:31ZMLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation10.1038/s41467-018-03563-82041-1723https://doaj.org/article/e70d4a2c123b46d1aff993ffe9991d7e2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03563-8https://doaj.org/toc/2041-1723MLL5 is an essential epigenetic modifier involved in cell cycle progression, chromatin architecture and hematopoiesis. Here the authors establish that MLL5 suppresses the innate immune response in a murine model of virus infection by targeting and promoting degradation of RIG-I.Peipei ZhouXiaodan DingXiaoling WanLulu LiuXiujie YuanWei ZhangXinhui HuiGuangxun MengHui XiaoBin LiJin ZhongFajian HouLihwen DengYan ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Peipei Zhou
Xiaodan Ding
Xiaoling Wan
Lulu Liu
Xiujie Yuan
Wei Zhang
Xinhui Hui
Guangxun Meng
Hui Xiao
Bin Li
Jin Zhong
Fajian Hou
Lihwen Deng
Yan Zhang
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
description MLL5 is an essential epigenetic modifier involved in cell cycle progression, chromatin architecture and hematopoiesis. Here the authors establish that MLL5 suppresses the innate immune response in a murine model of virus infection by targeting and promoting degradation of RIG-I.
format article
author Peipei Zhou
Xiaodan Ding
Xiaoling Wan
Lulu Liu
Xiujie Yuan
Wei Zhang
Xinhui Hui
Guangxun Meng
Hui Xiao
Bin Li
Jin Zhong
Fajian Hou
Lihwen Deng
Yan Zhang
author_facet Peipei Zhou
Xiaodan Ding
Xiaoling Wan
Lulu Liu
Xiujie Yuan
Wei Zhang
Xinhui Hui
Guangxun Meng
Hui Xiao
Bin Li
Jin Zhong
Fajian Hou
Lihwen Deng
Yan Zhang
author_sort Peipei Zhou
title MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_short MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_full MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_fullStr MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_full_unstemmed MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_sort mll5 suppresses antiviral innate immune response by facilitating stub1-mediated rig-i degradation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e70d4a2c123b46d1aff993ffe9991d7e
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AT guangxunmeng mll5suppressesantiviralinnateimmuneresponsebyfacilitatingstub1mediatedrigidegradation
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AT fajianhou mll5suppressesantiviralinnateimmuneresponsebyfacilitatingstub1mediatedrigidegradation
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