Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?

Background: Zolpidem is one of the most prescribed hypnotic drugs. In 2001, the World Health Organization alerted a risk of pharmacodependence associated with zolpidem. The French health authority decided in 2017 to enforce security on the prescription of zolpidem to reduce those risks. The aim of o...

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Autores principales:	Alexandra Jobert, Marion Istvan, Edouard-Jules Laforgue, Benoit Schreck, Caroline Victorri-Vigneau
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic use older people zolpidem Medicine R
Acceso en línea:	https://doaj.org/article/e70e49b9999a46ae93714d7e9ba73163
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spelling	oai:doaj.org-article:e70e49b9999a46ae93714d7e9ba731632021-11-25T17:51:06ZRegulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?10.3390/ijerph1822120991660-46011661-7827https://doaj.org/article/e70e49b9999a46ae93714d7e9ba731632021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12099https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: Zolpidem is one of the most prescribed hypnotic drugs. In 2001, the World Health Organization alerted a risk of pharmacodependence associated with zolpidem. The French health authority decided in 2017 to enforce security on the prescription of zolpidem to reduce those risks. The aim of our study was to evaluate the impact of regulatory framework implementation, secure prescription pad, on the prevalence and incidence of prescriptions of zolpidem according to the age. Methods: This study was based on an observational study using the French healthcare data system. Two age categories were defined: “younger” and “older” (<65 years, ≥65 years); in order to study the evolution of prevalence and incidence of zolpidem use in our two groups, two periods were defined, before and after the implementation of the measure. Results: The prevalence decreased in the younger population by 51% (4012 vs. 7948 consumers), while that of the older population decreased by 42% (4151 vs. 7282). This difference in our two groups, with a greater decrease in the younger people, is statistically significant compared to the older people. Conclusion: Our study showed that regulatory framework implementation and mandatory secure prescription pad is more effective for decreasing prevalence of zolpidem prescription for younger people compared to older people.Alexandra JobertMarion IstvanEdouard-Jules LaforgueBenoit SchreckCaroline Victorri-VigneauMDPI AGarticlechronic useolder peoplezolpidemMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12099, p 12099 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic use older people zolpidem Medicine R
spellingShingle	chronic use older people zolpidem Medicine R Alexandra Jobert Marion Istvan Edouard-Jules Laforgue Benoit Schreck Caroline Victorri-Vigneau Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?
description	Background: Zolpidem is one of the most prescribed hypnotic drugs. In 2001, the World Health Organization alerted a risk of pharmacodependence associated with zolpidem. The French health authority decided in 2017 to enforce security on the prescription of zolpidem to reduce those risks. The aim of our study was to evaluate the impact of regulatory framework implementation, secure prescription pad, on the prevalence and incidence of prescriptions of zolpidem according to the age. Methods: This study was based on an observational study using the French healthcare data system. Two age categories were defined: “younger” and “older” (<65 years, ≥65 years); in order to study the evolution of prevalence and incidence of zolpidem use in our two groups, two periods were defined, before and after the implementation of the measure. Results: The prevalence decreased in the younger population by 51% (4012 vs. 7948 consumers), while that of the older population decreased by 42% (4151 vs. 7282). This difference in our two groups, with a greater decrease in the younger people, is statistically significant compared to the older people. Conclusion: Our study showed that regulatory framework implementation and mandatory secure prescription pad is more effective for decreasing prevalence of zolpidem prescription for younger people compared to older people.
format	article
author	Alexandra Jobert Marion Istvan Edouard-Jules Laforgue Benoit Schreck Caroline Victorri-Vigneau
author_facet	Alexandra Jobert Marion Istvan Edouard-Jules Laforgue Benoit Schreck Caroline Victorri-Vigneau
author_sort	Alexandra Jobert
title	Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?
title_short	Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?
title_full	Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?
title_fullStr	Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?
title_full_unstemmed	Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?
title_sort	regulatory framework implementation for the prescription of zolpidem in france, what impact in the older people?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e70e49b9999a46ae93714d7e9ba73163
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Regulatory Framework Implementation for the Prescription of Zolpidem in France, What Impact in the Older People?

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