Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent increase in bone mass in female mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Candice B. Herber, William C. Krause, Liping Wang, James R. Bayrer, Alfred Li, Matthew Schmitz, Aaron Fields, Breanna Ford, Zhi Zhang, Michelle S. Reid, Daniel K. Nomura, Robert A. Nissenson, Stephanie M. Correa, Holly A. Ingraham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e716ce14ed5d4a069d7f3a182f6e641a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e716ce14ed5d4a069d7f3a182f6e641a
record_format	dspace
spelling	oai:doaj.org-article:e716ce14ed5d4a069d7f3a182f6e641a2021-12-02T16:57:08ZEstrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones10.1038/s41467-018-08046-42041-1723https://doaj.org/article/e716ce14ed5d4a069d7f3a182f6e641a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08046-4https://doaj.org/toc/2041-1723Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent increase in bone mass in female mice.Candice B. HerberWilliam C. KrauseLiping WangJames R. BayrerAlfred LiMatthew SchmitzAaron FieldsBreanna FordZhi ZhangMichelle S. ReidDaniel K. NomuraRobert A. NissensonStephanie M. CorreaHolly A. IngrahamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Candice B. Herber William C. Krause Liping Wang James R. Bayrer Alfred Li Matthew Schmitz Aaron Fields Breanna Ford Zhi Zhang Michelle S. Reid Daniel K. Nomura Robert A. Nissenson Stephanie M. Correa Holly A. Ingraham Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
description	Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent increase in bone mass in female mice.
format	article
author	Candice B. Herber William C. Krause Liping Wang James R. Bayrer Alfred Li Matthew Schmitz Aaron Fields Breanna Ford Zhi Zhang Michelle S. Reid Daniel K. Nomura Robert A. Nissenson Stephanie M. Correa Holly A. Ingraham
author_facet	Candice B. Herber William C. Krause Liping Wang James R. Bayrer Alfred Li Matthew Schmitz Aaron Fields Breanna Ford Zhi Zhang Michelle S. Reid Daniel K. Nomura Robert A. Nissenson Stephanie M. Correa Holly A. Ingraham
author_sort	Candice B. Herber
title	Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
title_short	Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
title_full	Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
title_fullStr	Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
title_full_unstemmed	Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
title_sort	estrogen signaling in arcuate kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e716ce14ed5d4a069d7f3a182f6e641a
work_keys_str_mv	AT candicebherber estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT williamckrause estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT lipingwang estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT jamesrbayrer estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT alfredli estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT matthewschmitz estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT aaronfields estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT breannaford estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT zhizhang estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT michellesreid estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT danielknomura estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT robertanissenson estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT stephaniemcorrea estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones AT hollyaingraham estrogensignalinginarcuatekiss1neuronssuppressesasexdependentfemalecircuitpromotingdensestrongbones
_version_	1718382654901977088

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones

Ejemplares similares