Deletion of Mfsd2b impairs thrombotic functions of platelets

Deletion of Mfsd2b impairs thrombotic functions of platelets

The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.

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Auteurs principaux: Madhuvanthi Chandrakanthan, Toan Quoc Nguyen, Zafrul Hasan, Sneha Muralidharan, Thiet Minh Vu, Aaron Wei Liang Li, Uyen Thanh Nha Le, Hoa Thi Thuy Ha, Sang-Ha Baik, Sock Hwee Tan, Juat Chin Foo, Markus R. Wenk, Amaury Cazenave-Gassiot, Federico Torta, Wei Yi Ong, Mark Yan Yee Chan, Long N. Nguyen
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/e716e244e510455898a0ba23f1fb858d
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Résumé:The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.

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