Deletion of Mfsd2b impairs thrombotic functions of platelets

The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.

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Autores principales:	Madhuvanthi Chandrakanthan, Toan Quoc Nguyen, Zafrul Hasan, Sneha Muralidharan, Thiet Minh Vu, Aaron Wei Liang Li, Uyen Thanh Nha Le, Hoa Thi Thuy Ha, Sang-Ha Baik, Sock Hwee Tan, Juat Chin Foo, Markus R. Wenk, Amaury Cazenave-Gassiot, Federico Torta, Wei Yi Ong, Mark Yan Yee Chan, Long N. Nguyen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e716e244e510455898a0ba23f1fb858d
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spelling	oai:doaj.org-article:e716e244e510455898a0ba23f1fb858d2021-12-02T15:51:06ZDeletion of Mfsd2b impairs thrombotic functions of platelets10.1038/s41467-021-22642-x2041-1723https://doaj.org/article/e716e244e510455898a0ba23f1fb858d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22642-xhttps://doaj.org/toc/2041-1723The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.Madhuvanthi ChandrakanthanToan Quoc NguyenZafrul HasanSneha MuralidharanThiet Minh VuAaron Wei Liang LiUyen Thanh Nha LeHoa Thi Thuy HaSang-Ha BaikSock Hwee TanJuat Chin FooMarkus R. WenkAmaury Cazenave-GassiotFederico TortaWei Yi OngMark Yan Yee ChanLong N. NguyenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madhuvanthi Chandrakanthan Toan Quoc Nguyen Zafrul Hasan Sneha Muralidharan Thiet Minh Vu Aaron Wei Liang Li Uyen Thanh Nha Le Hoa Thi Thuy Ha Sang-Ha Baik Sock Hwee Tan Juat Chin Foo Markus R. Wenk Amaury Cazenave-Gassiot Federico Torta Wei Yi Ong Mark Yan Yee Chan Long N. Nguyen Deletion of Mfsd2b impairs thrombotic functions of platelets
description	The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.
format	article
author	Madhuvanthi Chandrakanthan Toan Quoc Nguyen Zafrul Hasan Sneha Muralidharan Thiet Minh Vu Aaron Wei Liang Li Uyen Thanh Nha Le Hoa Thi Thuy Ha Sang-Ha Baik Sock Hwee Tan Juat Chin Foo Markus R. Wenk Amaury Cazenave-Gassiot Federico Torta Wei Yi Ong Mark Yan Yee Chan Long N. Nguyen
author_facet	Madhuvanthi Chandrakanthan Toan Quoc Nguyen Zafrul Hasan Sneha Muralidharan Thiet Minh Vu Aaron Wei Liang Li Uyen Thanh Nha Le Hoa Thi Thuy Ha Sang-Ha Baik Sock Hwee Tan Juat Chin Foo Markus R. Wenk Amaury Cazenave-Gassiot Federico Torta Wei Yi Ong Mark Yan Yee Chan Long N. Nguyen
author_sort	Madhuvanthi Chandrakanthan
title	Deletion of Mfsd2b impairs thrombotic functions of platelets
title_short	Deletion of Mfsd2b impairs thrombotic functions of platelets
title_full	Deletion of Mfsd2b impairs thrombotic functions of platelets
title_fullStr	Deletion of Mfsd2b impairs thrombotic functions of platelets
title_full_unstemmed	Deletion of Mfsd2b impairs thrombotic functions of platelets
title_sort	deletion of mfsd2b impairs thrombotic functions of platelets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e716e244e510455898a0ba23f1fb858d
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Deletion of Mfsd2b impairs thrombotic functions of platelets

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