Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction

Cataracts in diabetes mellitus lead to decreased visual function and blindness. Cataract surgery for diabetes mellitus has limitations and complications. The search for effective means of conservative cataract therapy continues. The review presents the analysis of data from scientific sources, mainl...

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Autores principales:	A. A. Spassov, L. V. Naumenko, Yu. A. Govorova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	diabetes mellitus cataract non-enzymatic glycation crystallins oxidative stress glycation end products active oxygen metabolites antiglycation compound Science Q
Acceso en línea:	https://doaj.org/article/e71c6ef41ed14e2e8adffd5bf313eef5
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spelling	oai:doaj.org-article:e71c6ef41ed14e2e8adffd5bf313eef52021-11-23T06:14:45ZFundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction2541-94202587-959610.29413/ABS.2021-6.2.13https://doaj.org/article/e71c6ef41ed14e2e8adffd5bf313eef52021-06-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2739https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Cataracts in diabetes mellitus lead to decreased visual function and blindness. Cataract surgery for diabetes mellitus has limitations and complications. The search for effective means of conservative cataract therapy continues. The review presents the analysis of data from scientific sources, mainly for 2015–2020 using Internet resources (PubMed, Web of Science, Medline, eLibrary.Ru, Cyberleninka). In the work, diabetic cataractogenesis is presented as a sum of interrelated pathobiochemical processes. The main ones are the polyol pathway of glucose conversion, non-enzymatic glycation and oxidative modification of lens proteins, which are enhanced in diabetes mellitus. The lens has a high protein content. The formation of high molecular weight protein aggregates is of particular importance for the appearance of light scattering zones and a decrease in lens transparency. This review presents data on anti-cataract compounds that affect post-translational crystallin modification, prevent osmotic and oxidative stress in the lens, and exhibit antiglycation properties. This information shows that the search for means of pharmacological correction of cataractogenesis should be carried out among compounds with antioxidant and antiglycation activity.A. A. SpassovL. V. NaumenkoYu. A. GovorovaScientific Сentre for Family Health and Human Reproduction Problemsarticlediabetes mellituscataractnon-enzymatic glycationcrystallinsoxidative stressglycation end productsactive oxygen metabolitesantiglycation compoundScienceQRUActa Biomedica Scientifica, Vol 6, Iss 2, Pp 114-125 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetes mellitus cataract non-enzymatic glycation crystallins oxidative stress glycation end products active oxygen metabolites antiglycation compound Science Q
spellingShingle	diabetes mellitus cataract non-enzymatic glycation crystallins oxidative stress glycation end products active oxygen metabolites antiglycation compound Science Q A. A. Spassov L. V. Naumenko Yu. A. Govorova Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
description	Cataracts in diabetes mellitus lead to decreased visual function and blindness. Cataract surgery for diabetes mellitus has limitations and complications. The search for effective means of conservative cataract therapy continues. The review presents the analysis of data from scientific sources, mainly for 2015–2020 using Internet resources (PubMed, Web of Science, Medline, eLibrary.Ru, Cyberleninka). In the work, diabetic cataractogenesis is presented as a sum of interrelated pathobiochemical processes. The main ones are the polyol pathway of glucose conversion, non-enzymatic glycation and oxidative modification of lens proteins, which are enhanced in diabetes mellitus. The lens has a high protein content. The formation of high molecular weight protein aggregates is of particular importance for the appearance of light scattering zones and a decrease in lens transparency. This review presents data on anti-cataract compounds that affect post-translational crystallin modification, prevent osmotic and oxidative stress in the lens, and exhibit antiglycation properties. This information shows that the search for means of pharmacological correction of cataractogenesis should be carried out among compounds with antioxidant and antiglycation activity.
format	article
author	A. A. Spassov L. V. Naumenko Yu. A. Govorova
author_facet	A. A. Spassov L. V. Naumenko Yu. A. Govorova
author_sort	A. A. Spassov
title	Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
title_short	Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
title_full	Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
title_fullStr	Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
title_full_unstemmed	Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction
title_sort	fundamentals of diabetic cataractogenesis and promising ways of its pharmacological correction
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/e71c6ef41ed14e2e8adffd5bf313eef5
work_keys_str_mv	AT aaspassov fundamentalsofdiabeticcataractogenesisandpromisingwaysofitspharmacologicalcorrection AT lvnaumenko fundamentalsofdiabeticcataractogenesisandpromisingwaysofitspharmacologicalcorrection AT yuagovorova fundamentalsofdiabeticcataractogenesisandpromisingwaysofitspharmacologicalcorrection
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Fundamentals of Diabetic Cataractogenesis and Promising Ways of its Pharmacological Correction

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