Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up

Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed Department of Ophthalmology, Benha University, Benha, Egypt Purpose: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. Patients and methods: This is a...

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Autores principales:	Heikal MA, Soliman TT, Fayed A, Hamed AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Corneal astigmatism Keratoconus Refractive astigmatism Trans-epithelial crosslinking Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e71d41bb37e149c0abe0858c8b7250f8
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spelling	oai:doaj.org-article:e71d41bb37e149c0abe0858c8b7250f82021-12-02T08:17:22ZEfficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up1177-5483https://doaj.org/article/e71d41bb37e149c0abe0858c8b7250f82017-04-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-transepithelial-corneal-collagen-crosslinking-for-keratoco-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed Department of Ophthalmology, Benha University, Benha, Egypt Purpose: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. Patients and methods: This is a prospective interventional consecutive study carried out on 30 eyes of 18 patients with progressive keratoconus who underwent TE-CLX using both ParaCel™ (riboflavin 0.25%, hydroxy propyl methyl cellulose, NaCl, ethylenediaminetetraacetic acid [EDTA], Tris, and benzalkonium chloride) and vibeX-Xtra (riboflavin 0.22%, phosphate-buffered saline solution). The procedure was carried out at Ebsar Eye Center in Egypt in the period from 2012 to 2014. The follow-up visits were scheduled on days 1, 3, 6, and 12 months after treatment. Results: There were statistically significant improvements (P<0.001) in the mean best-corrected visual acuity (0.54±0.22 preoperatively vs 0.61±0.19 at 12 months postoperatively), the mean manifest refraction spherical equivalent (MRSE; -6.16±3.90 diopters [D] preoperatively and -5.91±3.72 D at 12 months postoperatively), and the mean preoperative corneal astigmatism (-3.39±2.11 D preoperatively and -2.46±2.60 D at 12 months postoperatively). Conclusion: TE-CXL could halt the progression of keratoconus in adult patients. TE-CXL resulted in a statistically significant improvement in best-corrected visual acuity, manifest refraction, refractive and corneal astigmatism and K values in keratoconus patients at the 12-month follow-up. Larger sample sizes and longer follow-ups are required in order to make meaningful conclusions. Keywords: corneal astigmatism, refractive astigmatism, transepithelial crosslinking, progressive keratoconusHeikal MASoliman TTFayed AHamed AMDove Medical PressarticleCorneal astigmatismKeratoconusRefractive astigmatismTrans-epithelial crosslinkingOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 767-771 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Corneal astigmatism Keratoconus Refractive astigmatism Trans-epithelial crosslinking Ophthalmology RE1-994
spellingShingle	Corneal astigmatism Keratoconus Refractive astigmatism Trans-epithelial crosslinking Ophthalmology RE1-994 Heikal MA Soliman TT Fayed A Hamed AM Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
description	Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed Department of Ophthalmology, Benha University, Benha, Egypt Purpose: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. Patients and methods: This is a prospective interventional consecutive study carried out on 30 eyes of 18 patients with progressive keratoconus who underwent TE-CLX using both ParaCel™ (riboflavin 0.25%, hydroxy propyl methyl cellulose, NaCl, ethylenediaminetetraacetic acid [EDTA], Tris, and benzalkonium chloride) and vibeX-Xtra (riboflavin 0.22%, phosphate-buffered saline solution). The procedure was carried out at Ebsar Eye Center in Egypt in the period from 2012 to 2014. The follow-up visits were scheduled on days 1, 3, 6, and 12 months after treatment. Results: There were statistically significant improvements (P<0.001) in the mean best-corrected visual acuity (0.54±0.22 preoperatively vs 0.61±0.19 at 12 months postoperatively), the mean manifest refraction spherical equivalent (MRSE; -6.16±3.90 diopters [D] preoperatively and -5.91±3.72 D at 12 months postoperatively), and the mean preoperative corneal astigmatism (-3.39±2.11 D preoperatively and -2.46±2.60 D at 12 months postoperatively). Conclusion: TE-CXL could halt the progression of keratoconus in adult patients. TE-CXL resulted in a statistically significant improvement in best-corrected visual acuity, manifest refraction, refractive and corneal astigmatism and K values in keratoconus patients at the 12-month follow-up. Larger sample sizes and longer follow-ups are required in order to make meaningful conclusions. Keywords: corneal astigmatism, refractive astigmatism, transepithelial crosslinking, progressive keratoconus
format	article
author	Heikal MA Soliman TT Fayed A Hamed AM
author_facet	Heikal MA Soliman TT Fayed A Hamed AM
author_sort	Heikal MA
title	Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
title_short	Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
title_full	Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
title_fullStr	Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
title_full_unstemmed	Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
title_sort	efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e71d41bb37e149c0abe0858c8b7250f8
work_keys_str_mv	AT heikalma efficacyoftransepithelialcornealcollagencrosslinkingforkeratoconus12monthfollowup AT solimantt efficacyoftransepithelialcornealcollagencrosslinkingforkeratoconus12monthfollowup AT fayeda efficacyoftransepithelialcornealcollagencrosslinkingforkeratoconus12monthfollowup AT hamedam efficacyoftransepithelialcornealcollagencrosslinkingforkeratoconus12monthfollowup
_version_	1718398635143593984

Efficacy of transepithelial corneal collagen crosslinking for keratoconus: 12-month follow-up

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