In vivo reprogramming drives Kras-induced cancer development

In vivo reprogramming drives Kras-induced cancer development

Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development.

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Autores principales: Hirofumi Shibata, Shingo Komura, Yosuke Yamada, Nao Sankoda, Akito Tanaka, Tomoyo Ukai, Mio Kabata, Satoko Sakurai, Bunya Kuze, Knut Woltjen, Hironori Haga, Yatsuji Ito, Yoshiya Kawaguchi, Takuya Yamamoto, Yasuhiro Yamada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/e71dfb2ea18648a280e7955320885433
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spelling oai:doaj.org-article:e71dfb2ea18648a280e79553208854332021-12-02T15:34:27ZIn vivo reprogramming drives Kras-induced cancer development10.1038/s41467-018-04449-52041-1723https://doaj.org/article/e71dfb2ea18648a280e79553208854332018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04449-5https://doaj.org/toc/2041-1723Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development.Hirofumi ShibataShingo KomuraYosuke YamadaNao SankodaAkito TanakaTomoyo UkaiMio KabataSatoko SakuraiBunya KuzeKnut WoltjenHironori HagaYatsuji ItoYoshiya KawaguchiTakuya YamamotoYasuhiro YamadaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hirofumi Shibata
Shingo Komura
Yosuke Yamada
Nao Sankoda
Akito Tanaka
Tomoyo Ukai
Mio Kabata
Satoko Sakurai
Bunya Kuze
Knut Woltjen
Hironori Haga
Yatsuji Ito
Yoshiya Kawaguchi
Takuya Yamamoto
Yasuhiro Yamada
In vivo reprogramming drives Kras-induced cancer development
description Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development.
format article
author Hirofumi Shibata
Shingo Komura
Yosuke Yamada
Nao Sankoda
Akito Tanaka
Tomoyo Ukai
Mio Kabata
Satoko Sakurai
Bunya Kuze
Knut Woltjen
Hironori Haga
Yatsuji Ito
Yoshiya Kawaguchi
Takuya Yamamoto
Yasuhiro Yamada
author_facet Hirofumi Shibata
Shingo Komura
Yosuke Yamada
Nao Sankoda
Akito Tanaka
Tomoyo Ukai
Mio Kabata
Satoko Sakurai
Bunya Kuze
Knut Woltjen
Hironori Haga
Yatsuji Ito
Yoshiya Kawaguchi
Takuya Yamamoto
Yasuhiro Yamada
author_sort Hirofumi Shibata
title In vivo reprogramming drives Kras-induced cancer development
title_short In vivo reprogramming drives Kras-induced cancer development
title_full In vivo reprogramming drives Kras-induced cancer development
title_fullStr In vivo reprogramming drives Kras-induced cancer development
title_full_unstemmed In vivo reprogramming drives Kras-induced cancer development
title_sort in vivo reprogramming drives kras-induced cancer development
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e71dfb2ea18648a280e7955320885433
work_keys_str_mv AT hirofumishibata invivoreprogrammingdriveskrasinducedcancerdevelopment
AT shingokomura invivoreprogrammingdriveskrasinducedcancerdevelopment
AT yosukeyamada invivoreprogrammingdriveskrasinducedcancerdevelopment
AT naosankoda invivoreprogrammingdriveskrasinducedcancerdevelopment
AT akitotanaka invivoreprogrammingdriveskrasinducedcancerdevelopment
AT tomoyoukai invivoreprogrammingdriveskrasinducedcancerdevelopment
AT miokabata invivoreprogrammingdriveskrasinducedcancerdevelopment
AT satokosakurai invivoreprogrammingdriveskrasinducedcancerdevelopment
AT bunyakuze invivoreprogrammingdriveskrasinducedcancerdevelopment
AT knutwoltjen invivoreprogrammingdriveskrasinducedcancerdevelopment
AT hironorihaga invivoreprogrammingdriveskrasinducedcancerdevelopment
AT yatsujiito invivoreprogrammingdriveskrasinducedcancerdevelopment
AT yoshiyakawaguchi invivoreprogrammingdriveskrasinducedcancerdevelopment
AT takuyayamamoto invivoreprogrammingdriveskrasinducedcancerdevelopment
AT yasuhiroyamada invivoreprogrammingdriveskrasinducedcancerdevelopment
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