Neuropathological evidence of body-first vs. brain-first Lewy body disease

Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral...

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Autores principales:	Per Borghammer, Jacob Horsager, Katrine Andersen, Nathalie Van Den Berge, Anna Raunio, Shigeo Murayama, Laura Parkkinen, Liisa Myllykangas
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Lewy body Parkinson's disease Alpha-synuclein Dementia with Lewy bodies Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e724fb4b6980453890175ae589978beb
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id	oai:doaj.org-article:e724fb4b6980453890175ae589978beb
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spelling	oai:doaj.org-article:e724fb4b6980453890175ae589978beb2021-12-04T04:33:12ZNeuropathological evidence of body-first vs. brain-first Lewy body disease1095-953X10.1016/j.nbd.2021.105557https://doaj.org/article/e724fb4b6980453890175ae589978beb2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121003065https://doaj.org/toc/1095-953XAggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most abundant pathology in the “center of the brain”, including the amygdala, entorhinal cortex, and substantia nigra, and relatively less pathology in the lower brainstem and spinal autonomic nuclei. The recent body-first versus brain-first model of Lewy Body Disorders proposes that the initial pathogenic alpha-synuclein in some patients originates in the enteric nervous system with secondary spreading to the brain; and in other patients originates inside the CNS with secondary spreading to the lower brainstem and peripheral autonomic nervous system. Here, we use two existing post mortem datasets to explore the possibility that clinical body-first and brain-first subtypes are equivalent to the caudo-rostral and amygdala-centered patterns of Lewy pathology seen at post mortem.Per BorghammerJacob HorsagerKatrine AndersenNathalie Van Den BergeAnna RaunioShigeo MurayamaLaura ParkkinenLiisa MyllykangasElsevierarticleLewy bodyParkinson's diseaseAlpha-synucleinDementia with Lewy bodiesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 161, Iss , Pp 105557- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lewy body Parkinson's disease Alpha-synuclein Dementia with Lewy bodies Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Lewy body Parkinson's disease Alpha-synuclein Dementia with Lewy bodies Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Per Borghammer Jacob Horsager Katrine Andersen Nathalie Van Den Berge Anna Raunio Shigeo Murayama Laura Parkkinen Liisa Myllykangas Neuropathological evidence of body-first vs. brain-first Lewy body disease
description	Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most abundant pathology in the “center of the brain”, including the amygdala, entorhinal cortex, and substantia nigra, and relatively less pathology in the lower brainstem and spinal autonomic nuclei. The recent body-first versus brain-first model of Lewy Body Disorders proposes that the initial pathogenic alpha-synuclein in some patients originates in the enteric nervous system with secondary spreading to the brain; and in other patients originates inside the CNS with secondary spreading to the lower brainstem and peripheral autonomic nervous system. Here, we use two existing post mortem datasets to explore the possibility that clinical body-first and brain-first subtypes are equivalent to the caudo-rostral and amygdala-centered patterns of Lewy pathology seen at post mortem.
format	article
author	Per Borghammer Jacob Horsager Katrine Andersen Nathalie Van Den Berge Anna Raunio Shigeo Murayama Laura Parkkinen Liisa Myllykangas
author_facet	Per Borghammer Jacob Horsager Katrine Andersen Nathalie Van Den Berge Anna Raunio Shigeo Murayama Laura Parkkinen Liisa Myllykangas
author_sort	Per Borghammer
title	Neuropathological evidence of body-first vs. brain-first Lewy body disease
title_short	Neuropathological evidence of body-first vs. brain-first Lewy body disease
title_full	Neuropathological evidence of body-first vs. brain-first Lewy body disease
title_fullStr	Neuropathological evidence of body-first vs. brain-first Lewy body disease
title_full_unstemmed	Neuropathological evidence of body-first vs. brain-first Lewy body disease
title_sort	neuropathological evidence of body-first vs. brain-first lewy body disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e724fb4b6980453890175ae589978beb
work_keys_str_mv	AT perborghammer neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT jacobhorsager neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT katrineandersen neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT nathalievandenberge neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT annaraunio neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT shigeomurayama neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT lauraparkkinen neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease AT liisamyllykangas neuropathologicalevidenceofbodyfirstvsbrainfirstlewybodydisease
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Neuropathological evidence of body-first vs. brain-first Lewy body disease

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