Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease

Shihui Fu,1,* Tao Liu,2,* Leiming Luo,1 Ping Ye1 1Department of Geriatric Cardiology; 2Nanlou Ultrasound Department, Chinese People’s Liberation Army General Hospital, Beijing, People's Republic of China *These authors are joint first authors Background: Atrial fibrillation (AF)...

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Autores principales:	Fu S, Liu T, Luo L, Ye P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Atrial fibrillation chronic kidney disease coronary artery disease Chinese elderly mortality Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e72591e39f294e94b53e09dd7bc0023b
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spelling	oai:doaj.org-article:e72591e39f294e94b53e09dd7bc0023b2021-12-02T07:30:45ZDifferent types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease1178-1998https://doaj.org/article/e72591e39f294e94b53e09dd7bc0023b2014-02-01T00:00:00Zhttps://www.dovepress.com/different-types-of-atrial-fibrillation-renal-function-and-mortality-in-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Shihui Fu,1,* Tao Liu,2,* Leiming Luo,1 Ping Ye1 1Department of Geriatric Cardiology; 2Nanlou Ultrasound Department, Chinese People’s Liberation Army General Hospital, Beijing, People's Republic of China *These authors are joint first authors Background: Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between different types of AF, CKD, and mortality remains unclear, especially in elderly Chinese patients with coronary artery disease. Methods: This study comprised 1,050 patients of median age 86 (60–104) years with coronary artery disease. The end point was all-cause death during a mean follow-up of 417 days. Results: Of 219 patients identified to have AF, 128 had paroxysmal type, 44 had persistent type, and 47 had permanent type. After adjusting for confounders, the estimated glomerular filtration rate was lower and the prevalence of CKD was higher in patients with permanent AF but not in those with paroxysmal or persistent AF. During follow-up, 106 non-CKD patients and 112 CKD patients died; mortality was significantly higher in CKD patients with AF than in those without AF (36 [40.9%] versus 76 [26.8%]), but not in patients without CKD (17 [13.0%] versus 89 [16.3%]). In patients with CKD, paroxysmal AF was independently associated with higher mortality after adjustment but not persistent or permanent AF. No type of AF had an independent association with mortality in patients without CKD. Conclusion: All types of AF had a high prevalence. Permanent AF was independently associated with an increased prevalence of CKD and a decreased estimated glomerular filtration rate. Paroxysmal AF was an independent risk factor for survival in patients with CKD but not in those without CKD. Keywords: atrial fibrillation, chronic kidney disease, coronary artery disease, Chinese, elderly, mortalityFu SLiu TLuo LYe PDove Medical PressarticleAtrial fibrillationchronic kidney diseasecoronary artery diseaseChinese elderlymortalityGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 301-308 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atrial fibrillation chronic kidney disease coronary artery disease Chinese elderly mortality Geriatrics RC952-954.6
spellingShingle	Atrial fibrillation chronic kidney disease coronary artery disease Chinese elderly mortality Geriatrics RC952-954.6 Fu S Liu T Luo L Ye P Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease
description	Shihui Fu,1,* Tao Liu,2,* Leiming Luo,1 Ping Ye1 1Department of Geriatric Cardiology; 2Nanlou Ultrasound Department, Chinese People’s Liberation Army General Hospital, Beijing, People's Republic of China *These authors are joint first authors Background: Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between different types of AF, CKD, and mortality remains unclear, especially in elderly Chinese patients with coronary artery disease. Methods: This study comprised 1,050 patients of median age 86 (60–104) years with coronary artery disease. The end point was all-cause death during a mean follow-up of 417 days. Results: Of 219 patients identified to have AF, 128 had paroxysmal type, 44 had persistent type, and 47 had permanent type. After adjusting for confounders, the estimated glomerular filtration rate was lower and the prevalence of CKD was higher in patients with permanent AF but not in those with paroxysmal or persistent AF. During follow-up, 106 non-CKD patients and 112 CKD patients died; mortality was significantly higher in CKD patients with AF than in those without AF (36 [40.9%] versus 76 [26.8%]), but not in patients without CKD (17 [13.0%] versus 89 [16.3%]). In patients with CKD, paroxysmal AF was independently associated with higher mortality after adjustment but not persistent or permanent AF. No type of AF had an independent association with mortality in patients without CKD. Conclusion: All types of AF had a high prevalence. Permanent AF was independently associated with an increased prevalence of CKD and a decreased estimated glomerular filtration rate. Paroxysmal AF was an independent risk factor for survival in patients with CKD but not in those without CKD. Keywords: atrial fibrillation, chronic kidney disease, coronary artery disease, Chinese, elderly, mortality
format	article
author	Fu S Liu T Luo L Ye P
author_facet	Fu S Liu T Luo L Ye P
author_sort	Fu S
title	Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease
title_short	Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease
title_full	Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease
title_fullStr	Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease
title_full_unstemmed	Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease
title_sort	different types of atrial fibrillation, renal function, and mortality in elderly chinese patients with coronary artery disease
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/e72591e39f294e94b53e09dd7bc0023b
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Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease

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