Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in hum...

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Autores principales: Gang Liu, Debangsu Sil, Nunziata Maio, Wing-Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e72a170c1c0d4aa795c47a4475b86629
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spelling oai:doaj.org-article:e72a170c1c0d4aa795c47a4475b866292021-12-02T10:48:10ZHeme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase10.1038/s41467-020-20145-92041-1723https://doaj.org/article/e72a170c1c0d4aa795c47a4475b866292020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20145-9https://doaj.org/toc/2041-1723Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in human cells.Gang LiuDebangsu SilNunziata MaioWing-Hang TongJ. Martin BollingerCarsten KrebsTracey Ann RouaultNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gang Liu
Debangsu Sil
Nunziata Maio
Wing-Hang Tong
J. Martin Bollinger
Carsten Krebs
Tracey Ann Rouault
Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
description Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in human cells.
format article
author Gang Liu
Debangsu Sil
Nunziata Maio
Wing-Hang Tong
J. Martin Bollinger
Carsten Krebs
Tracey Ann Rouault
author_facet Gang Liu
Debangsu Sil
Nunziata Maio
Wing-Hang Tong
J. Martin Bollinger
Carsten Krebs
Tracey Ann Rouault
author_sort Gang Liu
title Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_short Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_full Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_fullStr Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_full_unstemmed Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
title_sort heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e72a170c1c0d4aa795c47a4475b86629
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AT debangsusil hemebiosynthesisdependsonpreviouslyunrecognizedacquisitionofironsulfurcofactorsinhumanaminolevulinicaciddehydratase
AT nunziatamaio hemebiosynthesisdependsonpreviouslyunrecognizedacquisitionofironsulfurcofactorsinhumanaminolevulinicaciddehydratase
AT winghangtong hemebiosynthesisdependsonpreviouslyunrecognizedacquisitionofironsulfurcofactorsinhumanaminolevulinicaciddehydratase
AT jmartinbollinger hemebiosynthesisdependsonpreviouslyunrecognizedacquisitionofironsulfurcofactorsinhumanaminolevulinicaciddehydratase
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