Regional metabolic and network changes in Meige syndrome

Abstract To contribute to the understanding of the aetiology and pathogenesis of Meige syndrome, the metabolic networks of patients with Meige syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed a...

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Autores principales:	Jiayu Liu, Lei Li, Yuan Li, Qian Wang, Ruen Liu, Hu Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e72ce7df5e4b417481b06c4be167c4cd
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spelling	oai:doaj.org-article:e72ce7df5e4b417481b06c4be167c4cd2021-12-02T18:49:28ZRegional metabolic and network changes in Meige syndrome10.1038/s41598-021-95333-82045-2322https://doaj.org/article/e72ce7df5e4b417481b06c4be167c4cd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95333-8https://doaj.org/toc/2045-2322Abstract To contribute to the understanding of the aetiology and pathogenesis of Meige syndrome, the metabolic networks of patients with Meige syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed and unmedicated primary Meige syndrome patients enrolled between September 2017 and September 2020 at the Department of Neurosurgery, Peking University People’s Hospital, and 50 age- and sex-matched healthy control subjects participated in the study. Metabolic connectivity and graph theory analysis were used to investigate metabolic network differences based on 18F-FDG-PET images. Glucose hypometabolism was detected in the left internal globus pallidus and parietal lobe, right frontal lobe and postcentral gyrus, and bilateral thalamus and cerebellum of patients with Meige syndrome. Clustering coefficients (Cps) (density threshold: 16–28%; P < 0.05) and shortest path lengths (Lps) (density threshold: 10–15%; P < 0.05) were higher in Meige syndrome patients than in healthy controls. Small-worldness was lower in Meige syndrome patients than in healthy controls, and centrality was significantly lower in the right superior occipital gyrus and pallidum and higher in the right thalamus. Hypometabolism in the globus pallidus and thalamus may indicate basal ganglia-thalamocortical motor circuit abnormalities as a pathogenic mechanism of Meige syndrome, providing a possible explanation for the efficacy of deep brain stimulation (DBS) in improving symptoms. Meige syndrome patients had abnormal small-world properties. Centrality changes in the right pallidus and thalamus verified the important roles of these regions in the pathogenesis of Meige syndrome.Jiayu LiuLei LiYuan LiQian WangRuen LiuHu DingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiayu Liu Lei Li Yuan Li Qian Wang Ruen Liu Hu Ding Regional metabolic and network changes in Meige syndrome
description	Abstract To contribute to the understanding of the aetiology and pathogenesis of Meige syndrome, the metabolic networks of patients with Meige syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed and unmedicated primary Meige syndrome patients enrolled between September 2017 and September 2020 at the Department of Neurosurgery, Peking University People’s Hospital, and 50 age- and sex-matched healthy control subjects participated in the study. Metabolic connectivity and graph theory analysis were used to investigate metabolic network differences based on 18F-FDG-PET images. Glucose hypometabolism was detected in the left internal globus pallidus and parietal lobe, right frontal lobe and postcentral gyrus, and bilateral thalamus and cerebellum of patients with Meige syndrome. Clustering coefficients (Cps) (density threshold: 16–28%; P < 0.05) and shortest path lengths (Lps) (density threshold: 10–15%; P < 0.05) were higher in Meige syndrome patients than in healthy controls. Small-worldness was lower in Meige syndrome patients than in healthy controls, and centrality was significantly lower in the right superior occipital gyrus and pallidum and higher in the right thalamus. Hypometabolism in the globus pallidus and thalamus may indicate basal ganglia-thalamocortical motor circuit abnormalities as a pathogenic mechanism of Meige syndrome, providing a possible explanation for the efficacy of deep brain stimulation (DBS) in improving symptoms. Meige syndrome patients had abnormal small-world properties. Centrality changes in the right pallidus and thalamus verified the important roles of these regions in the pathogenesis of Meige syndrome.
format	article
author	Jiayu Liu Lei Li Yuan Li Qian Wang Ruen Liu Hu Ding
author_facet	Jiayu Liu Lei Li Yuan Li Qian Wang Ruen Liu Hu Ding
author_sort	Jiayu Liu
title	Regional metabolic and network changes in Meige syndrome
title_short	Regional metabolic and network changes in Meige syndrome
title_full	Regional metabolic and network changes in Meige syndrome
title_fullStr	Regional metabolic and network changes in Meige syndrome
title_full_unstemmed	Regional metabolic and network changes in Meige syndrome
title_sort	regional metabolic and network changes in meige syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e72ce7df5e4b417481b06c4be167c4cd
work_keys_str_mv	AT jiayuliu regionalmetabolicandnetworkchangesinmeigesyndrome AT leili regionalmetabolicandnetworkchangesinmeigesyndrome AT yuanli regionalmetabolicandnetworkchangesinmeigesyndrome AT qianwang regionalmetabolicandnetworkchangesinmeigesyndrome AT ruenliu regionalmetabolicandnetworkchangesinmeigesyndrome AT huding regionalmetabolicandnetworkchangesinmeigesyndrome
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Regional metabolic and network changes in Meige syndrome

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