Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

Juntao Yin,1 Yantao Hou,2 Yuyun Yin,3 Xiaoyong Song1 1Department of Pharmaceutics, Huaihe Hospital Affiliated to Henan University, 2Henan Vocational College of Applied Technology, Kaifeng, 3Henan Provincial Institute of Food and Drug Control, Zhengzhou, People’s Republic of China Abstrac...

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Autores principales:	Yin J, Hou Y, Yin Y, Song X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Berberine Diabetes mellitus Nanostructured lipid carriers Selenium Bioavailability Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e72eab5360584e76b776654bb57f763b
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spelling	oai:doaj.org-article:e72eab5360584e76b776654bb57f763b2021-12-02T00:40:17ZSelenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect1178-2013https://doaj.org/article/e72eab5360584e76b776654bb57f763b2017-12-01T00:00:00Zhttps://www.dovepress.com/selenium-coated-nanostructured-lipid-carriers-used-for-oral-delivery-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Juntao Yin,1 Yantao Hou,2 Yuyun Yin,3 Xiaoyong Song1 1Department of Pharmaceutics, Huaihe Hospital Affiliated to Henan University, 2Henan Vocational College of Applied Technology, Kaifeng, 3Henan Provincial Institute of Food and Drug Control, Zhengzhou, People’s Republic of China Abstract: Diabetes mellitus is an incurable metabolic disorder that seriously threatens human health. At present, there is no effective medication available to defeat it. This work intended to develop selenium-coated nanostructured lipid carriers (SeNLCs) for enhancing the oral bioavailability and the curative effect of berberine, an antidiabetic phytomedicine. Berberine-loaded SeNLCs (BB-SeNLCs) were prepared by hot-melt dispersion/homogenization procedure followed by in situ reduction. BB-SeNLCs were characterized by particle size, morphology, entrapment efficiency (EE) and in vitro release. Pharmacokinetics of berberine solution, berberine-loaded NLCs (BB-NLCs) and BB-SeNLCs were studied in Sprague Dawley rats administered by oral gavage. The prepared BB-SeNLCs were around 160 nm in particle size with an EE of 90%. In addition, BB-SeNLCs exhibited a better sustained release of berberine compared to the plain NLCs. After oral administration, BB-SeNLCs greatly enhanced the oral bioavailability of berberine, which was approximately 6.63 times as much as that of berberine solution. The hypoglycemic effect of BB-SeNLCs was also significantly superior to that of BB-NLCs and berberine solution. It turned out that sustained drug release and good intestinal absorption, plus the synergy of selenium, were basically responsible for enhanced oral bioavailability and hypoglycemic effect. Our findings show that SeNLCs are promising nanocarriers for oral delivery of berberine to strengthen the antidiabetic action. Keywords: berberine, diabetes mellitus, nanostructured lipid carriers, selenium, bioavailability Yin JHou YYin YSong XDove Medical PressarticleBerberineDiabetes mellitusNanostructured lipid carriersSeleniumBioavailabilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8671-8680 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Berberine Diabetes mellitus Nanostructured lipid carriers Selenium Bioavailability Medicine (General) R5-920
spellingShingle	Berberine Diabetes mellitus Nanostructured lipid carriers Selenium Bioavailability Medicine (General) R5-920 Yin J Hou Y Yin Y Song X Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
description	Juntao Yin,1 Yantao Hou,2 Yuyun Yin,3 Xiaoyong Song1 1Department of Pharmaceutics, Huaihe Hospital Affiliated to Henan University, 2Henan Vocational College of Applied Technology, Kaifeng, 3Henan Provincial Institute of Food and Drug Control, Zhengzhou, People’s Republic of China Abstract: Diabetes mellitus is an incurable metabolic disorder that seriously threatens human health. At present, there is no effective medication available to defeat it. This work intended to develop selenium-coated nanostructured lipid carriers (SeNLCs) for enhancing the oral bioavailability and the curative effect of berberine, an antidiabetic phytomedicine. Berberine-loaded SeNLCs (BB-SeNLCs) were prepared by hot-melt dispersion/homogenization procedure followed by in situ reduction. BB-SeNLCs were characterized by particle size, morphology, entrapment efficiency (EE) and in vitro release. Pharmacokinetics of berberine solution, berberine-loaded NLCs (BB-NLCs) and BB-SeNLCs were studied in Sprague Dawley rats administered by oral gavage. The prepared BB-SeNLCs were around 160 nm in particle size with an EE of 90%. In addition, BB-SeNLCs exhibited a better sustained release of berberine compared to the plain NLCs. After oral administration, BB-SeNLCs greatly enhanced the oral bioavailability of berberine, which was approximately 6.63 times as much as that of berberine solution. The hypoglycemic effect of BB-SeNLCs was also significantly superior to that of BB-NLCs and berberine solution. It turned out that sustained drug release and good intestinal absorption, plus the synergy of selenium, were basically responsible for enhanced oral bioavailability and hypoglycemic effect. Our findings show that SeNLCs are promising nanocarriers for oral delivery of berberine to strengthen the antidiabetic action. Keywords: berberine, diabetes mellitus, nanostructured lipid carriers, selenium, bioavailability
format	article
author	Yin J Hou Y Yin Y Song X
author_facet	Yin J Hou Y Yin Y Song X
author_sort	Yin J
title	Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
title_short	Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
title_full	Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
title_fullStr	Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
title_full_unstemmed	Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
title_sort	selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e72eab5360584e76b776654bb57f763b
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Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

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