Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A

Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A

Neisseria meningitidis capsular polysaccharide (CPS) is a major virulence factor and vaccine formulations against Neisseria meningitidis serogroup A (NmA) contain O-acetylated CPS. Here, the authors provide mechanistic insights into CPS O-acetylation in NmA by determining the crystal structure of th...

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Autores principales: Timm Fiebig, Johannes T. Cramer, Andrea Bethe, Petra Baruch, Ute Curth, Jana I. Führing, Falk F. R. Buettner, Ulrich Vogel, Mario Schubert, Roman Fedorov, Martina Mühlenhoff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/e72fba9673214d1d84ba89818eb3a079
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