What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations
ABSTRACT Chemical signaling between cells is an effective way to coordinate behavior within a community. Although cell-to-cell signaling has mostly been studied in single species, it is now appreciated that the sensing of chemical signals across kingdoms can be an important regulator of nutrient acq...
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American Society for Microbiology
2016
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oai:doaj.org-article:e731413115c64e8d9ce2fddb4f19514f2021-11-15T15:41:42ZWhat a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations10.1128/mBio.01748-152150-7511https://doaj.org/article/e731413115c64e8d9ce2fddb4f19514f2016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01748-15https://doaj.org/toc/2150-7511ABSTRACT Chemical signaling between cells is an effective way to coordinate behavior within a community. Although cell-to-cell signaling has mostly been studied in single species, it is now appreciated that the sensing of chemical signals across kingdoms can be an important regulator of nutrient acquisition, virulence, and host defense. In this review, we focus on the role of interkingdom signaling in the interactions that occur between bacterial pathogens and their mammalian hosts. We discuss the quorum-sensing (QS) systems and other mechanisms used by these bacteria to sense, respond to, and modulate host signals that include hormones, immune factors, and nutrients. We also describe cross talk between these signaling pathways and strategies used by the host to interfere with bacterial signaling, highlighting the complex bidirectional signaling networks that are established across kingdoms.Melissa M. KendallVanessa SperandioAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Melissa M. Kendall Vanessa Sperandio What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations |
| description |
ABSTRACT Chemical signaling between cells is an effective way to coordinate behavior within a community. Although cell-to-cell signaling has mostly been studied in single species, it is now appreciated that the sensing of chemical signals across kingdoms can be an important regulator of nutrient acquisition, virulence, and host defense. In this review, we focus on the role of interkingdom signaling in the interactions that occur between bacterial pathogens and their mammalian hosts. We discuss the quorum-sensing (QS) systems and other mechanisms used by these bacteria to sense, respond to, and modulate host signals that include hormones, immune factors, and nutrients. We also describe cross talk between these signaling pathways and strategies used by the host to interfere with bacterial signaling, highlighting the complex bidirectional signaling networks that are established across kingdoms. |
| format |
article |
| author |
Melissa M. Kendall Vanessa Sperandio |
| author_facet |
Melissa M. Kendall Vanessa Sperandio |
| author_sort |
Melissa M. Kendall |
| title |
What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations |
| title_short |
What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations |
| title_full |
What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations |
| title_fullStr |
What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations |
| title_full_unstemmed |
What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations |
| title_sort |
what a dinner party! mechanisms and functions of interkingdom signaling in host-pathogen associations |
| publisher |
American Society for Microbiology |
| publishDate |
2016 |
| url |
https://doaj.org/article/e731413115c64e8d9ce2fddb4f19514f |
| work_keys_str_mv |
AT melissamkendall whatadinnerpartymechanismsandfunctionsofinterkingdomsignalinginhostpathogenassociations AT vanessasperandio whatadinnerpartymechanismsandfunctionsofinterkingdomsignalinginhostpathogenassociations |
| _version_ |
1718427678380392448 |