Role of LGI1 protein in synaptic transmission: From physiology to pathology

Leucine-Rich Glioma Inactivated protein 1 (LGI1) is a secreted neuronal protein highly expressed in the central nervous system and high amount are found in the hippocampus. An alteration of its function has been described in few families of patients with autosomal dominant temporal lobe epilepsy (AD...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elodie Fels, Sergio Muñiz-Castrillo, Alberto Vogrig, Bastien Joubert, Jérôme Honnorat, Olivier Pascual
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Autoimmune limbic encephalitis Autosomal dominant temporal lobe epilepsy Trans-synaptic complex Synaptic transmission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e7346d42a6264fbcb9d12dd8e9915067
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7346d42a6264fbcb9d12dd8e9915067
record_format	dspace
spelling	oai:doaj.org-article:e7346d42a6264fbcb9d12dd8e99150672021-11-12T04:26:33ZRole of LGI1 protein in synaptic transmission: From physiology to pathology1095-953X10.1016/j.nbd.2021.105537https://doaj.org/article/e7346d42a6264fbcb9d12dd8e99150672021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0969996121002862https://doaj.org/toc/1095-953XLeucine-Rich Glioma Inactivated protein 1 (LGI1) is a secreted neuronal protein highly expressed in the central nervous system and high amount are found in the hippocampus. An alteration of its function has been described in few families of patients with autosomal dominant temporal lobe epilepsy (ADLTE) or with autoimmune limbic encephalitis (LE), both characterized by epileptic seizures. Studies have shown that LGI1 plays an essential role during development, but also in neuronal excitability through an action on voltage-gated potassium Kv1.1 channels, and in synaptic transmission by regulating the surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-R). Over the last decade, a growing number of studies investigating LGI1 functions have been published. They aimed to improve the understanding of LGI1 function in the regulation of neuronal networks using different animal and cellular models. LGI1 appears to be a major actor of synaptic regulation by modulating trans-synaptically pre- and post-synaptic proteins. In this review, we will focus on LGI1 binding partners, “A Disintegrin And Metalloprotease (ADAM) 22 and 23”, the complex they form at the synapse, and will discuss the effects of LGI1 on neuronal excitability and synaptic transmission in physiological and pathological conditions. Finally, we will highlight new insights regarding N-terminal Leucine-Rich Repeat (LRR) domain and C-terminal Epitempin repeat (EPTP) domain and their potentially distinct role in LGI1 function.Elodie FelsSergio Muñiz-CastrilloAlberto VogrigBastien JoubertJérôme HonnoratOlivier PascualElsevierarticleAutoimmune limbic encephalitisAutosomal dominant temporal lobe epilepsyTrans-synaptic complexSynaptic transmissionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeurobiology of Disease, Vol 160, Iss , Pp 105537- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autoimmune limbic encephalitis Autosomal dominant temporal lobe epilepsy Trans-synaptic complex Synaptic transmission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Autoimmune limbic encephalitis Autosomal dominant temporal lobe epilepsy Trans-synaptic complex Synaptic transmission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Elodie Fels Sergio Muñiz-Castrillo Alberto Vogrig Bastien Joubert Jérôme Honnorat Olivier Pascual Role of LGI1 protein in synaptic transmission: From physiology to pathology
description	Leucine-Rich Glioma Inactivated protein 1 (LGI1) is a secreted neuronal protein highly expressed in the central nervous system and high amount are found in the hippocampus. An alteration of its function has been described in few families of patients with autosomal dominant temporal lobe epilepsy (ADLTE) or with autoimmune limbic encephalitis (LE), both characterized by epileptic seizures. Studies have shown that LGI1 plays an essential role during development, but also in neuronal excitability through an action on voltage-gated potassium Kv1.1 channels, and in synaptic transmission by regulating the surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-R). Over the last decade, a growing number of studies investigating LGI1 functions have been published. They aimed to improve the understanding of LGI1 function in the regulation of neuronal networks using different animal and cellular models. LGI1 appears to be a major actor of synaptic regulation by modulating trans-synaptically pre- and post-synaptic proteins. In this review, we will focus on LGI1 binding partners, “A Disintegrin And Metalloprotease (ADAM) 22 and 23”, the complex they form at the synapse, and will discuss the effects of LGI1 on neuronal excitability and synaptic transmission in physiological and pathological conditions. Finally, we will highlight new insights regarding N-terminal Leucine-Rich Repeat (LRR) domain and C-terminal Epitempin repeat (EPTP) domain and their potentially distinct role in LGI1 function.
format	article
author	Elodie Fels Sergio Muñiz-Castrillo Alberto Vogrig Bastien Joubert Jérôme Honnorat Olivier Pascual
author_facet	Elodie Fels Sergio Muñiz-Castrillo Alberto Vogrig Bastien Joubert Jérôme Honnorat Olivier Pascual
author_sort	Elodie Fels
title	Role of LGI1 protein in synaptic transmission: From physiology to pathology
title_short	Role of LGI1 protein in synaptic transmission: From physiology to pathology
title_full	Role of LGI1 protein in synaptic transmission: From physiology to pathology
title_fullStr	Role of LGI1 protein in synaptic transmission: From physiology to pathology
title_full_unstemmed	Role of LGI1 protein in synaptic transmission: From physiology to pathology
title_sort	role of lgi1 protein in synaptic transmission: from physiology to pathology
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e7346d42a6264fbcb9d12dd8e9915067
work_keys_str_mv	AT elodiefels roleoflgi1proteininsynaptictransmissionfromphysiologytopathology AT sergiomunizcastrillo roleoflgi1proteininsynaptictransmissionfromphysiologytopathology AT albertovogrig roleoflgi1proteininsynaptictransmissionfromphysiologytopathology AT bastienjoubert roleoflgi1proteininsynaptictransmissionfromphysiologytopathology AT jeromehonnorat roleoflgi1proteininsynaptictransmissionfromphysiologytopathology AT olivierpascual roleoflgi1proteininsynaptictransmissionfromphysiologytopathology
_version_	1718431322806943744

Role of LGI1 protein in synaptic transmission: From physiology to pathology

Ejemplares similares