Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is required for maintaining AMPAR-mediated synaptic transmi...

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Autores principales:	Joshua C. Brown, Amber Petersen, Ling Zhong, Miranda L. Himelright, Jessica A. Murphy, Randall S. Walikonis, Nashaat Z. Gerges
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e7365a0bc59244df82f32d08406fd3db
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spelling	oai:doaj.org-article:e7365a0bc59244df82f32d08406fd3db2021-12-02T15:34:51ZBidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression10.1038/ncomms110802041-1723https://doaj.org/article/e7365a0bc59244df82f32d08406fd3db2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11080https://doaj.org/toc/2041-1723BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is required for maintaining AMPAR-mediated synaptic transmission.Joshua C. BrownAmber PetersenLing ZhongMiranda L. HimelrightJessica A. MurphyRandall S. WalikonisNashaat Z. GergesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua C. Brown Amber Petersen Ling Zhong Miranda L. Himelright Jessica A. Murphy Randall S. Walikonis Nashaat Z. Gerges Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
description	BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is required for maintaining AMPAR-mediated synaptic transmission.
format	article
author	Joshua C. Brown Amber Petersen Ling Zhong Miranda L. Himelright Jessica A. Murphy Randall S. Walikonis Nashaat Z. Gerges
author_facet	Joshua C. Brown Amber Petersen Ling Zhong Miranda L. Himelright Jessica A. Murphy Randall S. Walikonis Nashaat Z. Gerges
author_sort	Joshua C. Brown
title	Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
title_short	Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
title_full	Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
title_fullStr	Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
title_full_unstemmed	Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
title_sort	bidirectional regulation of synaptic transmission by brag1/iqsec2 and its requirement in long-term depression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e7365a0bc59244df82f32d08406fd3db
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Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

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