Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is required for maintaining AMPAR-mediated synaptic transmi...

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Autores principales: Joshua C. Brown, Amber Petersen, Ling Zhong, Miranda L. Himelright, Jessica A. Murphy, Randall S. Walikonis, Nashaat Z. Gerges
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/e7365a0bc59244df82f32d08406fd3db
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