A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing
The advent of single-cell RNA sequencing has revealed significant transcriptional heterogeneity in cancer, but its relationship to genomic heterogeneity remains unclear. Focusing on acute myeloid leukemia samples, the authors describe a general approach for linking mutation-containing cells to their...
Enregistré dans:
Auteurs principaux: | Allegra A. Petti, Stephen R. Williams, Christopher A. Miller, Ian T. Fiddes, Sridhar N. Srivatsan, David Y. Chen, Catrina C. Fronick, Robert S. Fulton, Deanna M. Church, Timothy J. Ley |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/e7387f8418fd4439a8a668e9564cc12b |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Repression of GSK3 restores NK cell cytotoxicity in AML patients
par: Reshmi Parameswaran, et autres
Publié: (2016) -
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
par: Andrew L. Young, et autres
Publié: (2016) -
A B-cell developmental gene regulatory network is activated in infant AML.
par: Hamid Bolouri, et autres
Publié: (2021) -
A B-cell developmental gene regulatory network is activated in infant AML
par: Hamid Bolouri, et autres
Publié: (2021) -
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
par: Arvind Singh Mer, et autres
Publié: (2021)