Interleukin 37 promotes angiogenesis through TGF-β signaling

Abstract IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts w...

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Autores principales:	Mengmeng Zhao, Yongguang Hu, Jiayi Jin, Ying Yu, Shanshan Zhang, Jingjing Cao, Yuanfen Zhai, Rongbin Wei, Juanjuan Shou, Wenping Cai, Shangfeng Liu, Xiaoping Yang, Guo-Tong Xu, Jianhua Yang, David B. Corry, Shao Bo Su, Xialin Liu, Tianshu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e73b8ca65f3f4f5c849d6edbe4ff39d1
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spelling	oai:doaj.org-article:e73b8ca65f3f4f5c849d6edbe4ff39d12021-12-02T11:52:24ZInterleukin 37 promotes angiogenesis through TGF-β signaling10.1038/s41598-017-06124-z2045-2322https://doaj.org/article/e73b8ca65f3f4f5c849d6edbe4ff39d12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06124-zhttps://doaj.org/toc/2045-2322Abstract IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts with IL-37, and potently enhances the binding affinity of IL-37 to the ALK1 receptor complex, thus allowing IL-37 to signal through ALK1 to activate pro-angiogenic responses. We further show that TGF-β and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy. The result suggests that IL-37 induces pro-angiogenic responses through TGF-β, which may act as the bridging molecule that mediates IL-37 binding to the TGF-β receptor complex.Mengmeng ZhaoYongguang HuJiayi JinYing YuShanshan ZhangJingjing CaoYuanfen ZhaiRongbin WeiJuanjuan ShouWenping CaiShangfeng LiuXiaoping YangGuo-Tong XuJianhua YangDavid B. CorryShao Bo SuXialin LiuTianshu YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengmeng Zhao Yongguang Hu Jiayi Jin Ying Yu Shanshan Zhang Jingjing Cao Yuanfen Zhai Rongbin Wei Juanjuan Shou Wenping Cai Shangfeng Liu Xiaoping Yang Guo-Tong Xu Jianhua Yang David B. Corry Shao Bo Su Xialin Liu Tianshu Yang Interleukin 37 promotes angiogenesis through TGF-β signaling
description	Abstract IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts with IL-37, and potently enhances the binding affinity of IL-37 to the ALK1 receptor complex, thus allowing IL-37 to signal through ALK1 to activate pro-angiogenic responses. We further show that TGF-β and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy. The result suggests that IL-37 induces pro-angiogenic responses through TGF-β, which may act as the bridging molecule that mediates IL-37 binding to the TGF-β receptor complex.
format	article
author	Mengmeng Zhao Yongguang Hu Jiayi Jin Ying Yu Shanshan Zhang Jingjing Cao Yuanfen Zhai Rongbin Wei Juanjuan Shou Wenping Cai Shangfeng Liu Xiaoping Yang Guo-Tong Xu Jianhua Yang David B. Corry Shao Bo Su Xialin Liu Tianshu Yang
author_facet	Mengmeng Zhao Yongguang Hu Jiayi Jin Ying Yu Shanshan Zhang Jingjing Cao Yuanfen Zhai Rongbin Wei Juanjuan Shou Wenping Cai Shangfeng Liu Xiaoping Yang Guo-Tong Xu Jianhua Yang David B. Corry Shao Bo Su Xialin Liu Tianshu Yang
author_sort	Mengmeng Zhao
title	Interleukin 37 promotes angiogenesis through TGF-β signaling
title_short	Interleukin 37 promotes angiogenesis through TGF-β signaling
title_full	Interleukin 37 promotes angiogenesis through TGF-β signaling
title_fullStr	Interleukin 37 promotes angiogenesis through TGF-β signaling
title_full_unstemmed	Interleukin 37 promotes angiogenesis through TGF-β signaling
title_sort	interleukin 37 promotes angiogenesis through tgf-β signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e73b8ca65f3f4f5c849d6edbe4ff39d1
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Interleukin 37 promotes angiogenesis through TGF-β signaling

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