Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. Here, Ku et al., identify SARS-CoV-2 neutralizing antibodies from a phage library and identify an antibody combination that prevents viral escape and protects mice from viral challenge.

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Detalles Bibliográficos
Autores principales: Zhiqiang Ku, Xuping Xie, Edgar Davidson, Xiaohua Ye, Hang Su, Vineet D. Menachery, Yize Li, Zihao Yuan, Xianwen Zhang, Antonio E. Muruato, Ariadna Grinyo i Escuer, Breanna Tyrell, Kyle Doolan, Benjamin J. Doranz, Daniel Wrapp, Paul F. Bates, Jason S. McLellan, Susan R. Weiss, Ningyan Zhang, Pei-Yong Shi, Zhiqiang An
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/e73c300255c0401fa28523fb9eca7f9f
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Descripción
Sumario:Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. Here, Ku et al., identify SARS-CoV-2 neutralizing antibodies from a phage library and identify an antibody combination that prevents viral escape and protects mice from viral challenge.

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