Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape
Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. Here, Ku et al., identify SARS-CoV-2 neutralizing antibodies from a phage library and identify an antibody combination that prevents viral escape and protects mice from viral challenge.
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Nature Portfolio
2021
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oai:doaj.org-article:e73c300255c0401fa28523fb9eca7f9f2021-12-02T13:51:03ZMolecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape10.1038/s41467-020-20789-72041-1723https://doaj.org/article/e73c300255c0401fa28523fb9eca7f9f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20789-7https://doaj.org/toc/2041-1723Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. Here, Ku et al., identify SARS-CoV-2 neutralizing antibodies from a phage library and identify an antibody combination that prevents viral escape and protects mice from viral challenge.Zhiqiang KuXuping XieEdgar DavidsonXiaohua YeHang SuVineet D. MenacheryYize LiZihao YuanXianwen ZhangAntonio E. MuruatoAriadna Grinyo i EscuerBreanna TyrellKyle DoolanBenjamin J. DoranzDaniel WrappPaul F. BatesJason S. McLellanSusan R. WeissNingyan ZhangPei-Yong ShiZhiqiang AnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zhiqiang Ku Xuping Xie Edgar Davidson Xiaohua Ye Hang Su Vineet D. Menachery Yize Li Zihao Yuan Xianwen Zhang Antonio E. Muruato Ariadna Grinyo i Escuer Breanna Tyrell Kyle Doolan Benjamin J. Doranz Daniel Wrapp Paul F. Bates Jason S. McLellan Susan R. Weiss Ningyan Zhang Pei-Yong Shi Zhiqiang An Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |
| description |
Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. Here, Ku et al., identify SARS-CoV-2 neutralizing antibodies from a phage library and identify an antibody combination that prevents viral escape and protects mice from viral challenge. |
| format |
article |
| author |
Zhiqiang Ku Xuping Xie Edgar Davidson Xiaohua Ye Hang Su Vineet D. Menachery Yize Li Zihao Yuan Xianwen Zhang Antonio E. Muruato Ariadna Grinyo i Escuer Breanna Tyrell Kyle Doolan Benjamin J. Doranz Daniel Wrapp Paul F. Bates Jason S. McLellan Susan R. Weiss Ningyan Zhang Pei-Yong Shi Zhiqiang An |
| author_facet |
Zhiqiang Ku Xuping Xie Edgar Davidson Xiaohua Ye Hang Su Vineet D. Menachery Yize Li Zihao Yuan Xianwen Zhang Antonio E. Muruato Ariadna Grinyo i Escuer Breanna Tyrell Kyle Doolan Benjamin J. Doranz Daniel Wrapp Paul F. Bates Jason S. McLellan Susan R. Weiss Ningyan Zhang Pei-Yong Shi Zhiqiang An |
| author_sort |
Zhiqiang Ku |
| title |
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |
| title_short |
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |
| title_full |
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |
| title_fullStr |
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |
| title_full_unstemmed |
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape |
| title_sort |
molecular determinants and mechanism for antibody cocktail preventing sars-cov-2 escape |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e73c300255c0401fa28523fb9eca7f9f |
| work_keys_str_mv |
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| _version_ |
1718392472020713472 |