Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients

Abstract Post-thrombotic syndrome (PTS) is a common complication of deep vein thrombosis (DVT). Little is known about the involvement of adipokines in the pathogenesis of DVT. We evaluated whether adipokines can predict PTS. In a prospective cohort study, 320 DVT patients aged 70 years or less were...

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Autores principales:	Sandra Mrozinska, Joanna Cieslik, Elżbieta Broniatowska, Anetta Undas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e741ba50b756486a8bd5d05289893698
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spelling	oai:doaj.org-article:e741ba50b756486a8bd5d052898936982021-12-02T16:08:13ZElevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients10.1038/s41598-018-25135-y2045-2322https://doaj.org/article/e741ba50b756486a8bd5d052898936982018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25135-yhttps://doaj.org/toc/2045-2322Abstract Post-thrombotic syndrome (PTS) is a common complication of deep vein thrombosis (DVT). Little is known about the involvement of adipokines in the pathogenesis of DVT. We evaluated whether adipokines can predict PTS. In a prospective cohort study, 320 DVT patients aged 70 years or less were enrolled. Serum adiponectin, leptin and resistin levels were measured three months since the index first-ever DVT. After 2 years’ follow-up PTS was diagnosed in 83 of 309 available patients (26.9%) who had 13.9% lower adiponectin and 16% higher leptin levels compared with the remainder (both p < 0.0001). No PTS-associated differences in C-reactive protein, fibrinogen, D-dimer, plasminogen activator inhibitor-1 and resistin were observed. The multivariable logistic regression adjusted for age, sex, obesity and tissue plasminogen activator (tPa) showed that lower adiponectin (odds ratio [OR], 0.42; 95% confidence interval [CI], 0.31–0.56) and higher leptin levels (OR, 1.49; 95% CI, 1.31–1.69) are independent predictors for PTS. Obesity-stratified logistic regression analysis confirmed that lower adiponectin (OR, 0.49; 95% CI, 0.38–0.64) and higher leptin (OR, 1.41; 95% Cl, 1.25–1.58) levels predicted PTS. Our findings showed that lower adiponectin and higher leptin measured 3 months after DVT, regardless of obesity, can independently predict PTS, which suggests novel links between adipokines and thrombosis.Sandra MrozinskaJoanna CieslikElżbieta BroniatowskaAnetta UndasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Mrozinska Joanna Cieslik Elżbieta Broniatowska Anetta Undas Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
description	Abstract Post-thrombotic syndrome (PTS) is a common complication of deep vein thrombosis (DVT). Little is known about the involvement of adipokines in the pathogenesis of DVT. We evaluated whether adipokines can predict PTS. In a prospective cohort study, 320 DVT patients aged 70 years or less were enrolled. Serum adiponectin, leptin and resistin levels were measured three months since the index first-ever DVT. After 2 years’ follow-up PTS was diagnosed in 83 of 309 available patients (26.9%) who had 13.9% lower adiponectin and 16% higher leptin levels compared with the remainder (both p < 0.0001). No PTS-associated differences in C-reactive protein, fibrinogen, D-dimer, plasminogen activator inhibitor-1 and resistin were observed. The multivariable logistic regression adjusted for age, sex, obesity and tissue plasminogen activator (tPa) showed that lower adiponectin (odds ratio [OR], 0.42; 95% confidence interval [CI], 0.31–0.56) and higher leptin levels (OR, 1.49; 95% CI, 1.31–1.69) are independent predictors for PTS. Obesity-stratified logistic regression analysis confirmed that lower adiponectin (OR, 0.49; 95% CI, 0.38–0.64) and higher leptin (OR, 1.41; 95% Cl, 1.25–1.58) levels predicted PTS. Our findings showed that lower adiponectin and higher leptin measured 3 months after DVT, regardless of obesity, can independently predict PTS, which suggests novel links between adipokines and thrombosis.
format	article
author	Sandra Mrozinska Joanna Cieslik Elżbieta Broniatowska Anetta Undas
author_facet	Sandra Mrozinska Joanna Cieslik Elżbieta Broniatowska Anetta Undas
author_sort	Sandra Mrozinska
title	Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
title_short	Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
title_full	Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
title_fullStr	Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
title_full_unstemmed	Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
title_sort	elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e741ba50b756486a8bd5d05289893698
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Elevated leptin and decreased adiponectin independently predict the post-thrombotic syndrome in obese and non-obese patients

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