Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

Abstract The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to aortic constriction-induced cardiac...

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Bibliographic Details
Main Authors: Kim Han, Shahin Hassanzadeh, Komudi Singh, Sara Menazza, Tiffany T. Nguyen, Mark V. Stevens, An Nguyen, Hong San, Stasia A. Anderson, Yongshun Lin, Jizhong Zou, Elizabeth Murphy, Michael N. Sack
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/e74432eb6d7b4605b5186f619f445cc1
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https://doaj.org/article/e74432eb6d7b4605b5186f619f445cc1

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