Two-tier supramolecular encapsulation of small molecules in a protein cage

Protein cages are used for encapsulation of macromolecules such as proteins and nucleic acids. Here, the authors report a strategy to encapsulate poorly soluble small molecules within porous protein cages through capsid-templated micelle formation and show that the resulting lipoprotein-like cages e...

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Autores principales:	Thomas G. W. Edwardson, Stephan Tetter, Donald Hilvert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e746860bb4984ecabeb4e17acef42687
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spelling	oai:doaj.org-article:e746860bb4984ecabeb4e17acef426872021-12-02T17:31:55ZTwo-tier supramolecular encapsulation of small molecules in a protein cage10.1038/s41467-020-19112-12041-1723https://doaj.org/article/e746860bb4984ecabeb4e17acef426872020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19112-1https://doaj.org/toc/2041-1723Protein cages are used for encapsulation of macromolecules such as proteins and nucleic acids. Here, the authors report a strategy to encapsulate poorly soluble small molecules within porous protein cages through capsid-templated micelle formation and show that the resulting lipoprotein-like cages enhance the cellular delivery of these molecules.Thomas G. W. EdwardsonStephan TetterDonald HilvertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas G. W. Edwardson Stephan Tetter Donald Hilvert Two-tier supramolecular encapsulation of small molecules in a protein cage
description	Protein cages are used for encapsulation of macromolecules such as proteins and nucleic acids. Here, the authors report a strategy to encapsulate poorly soluble small molecules within porous protein cages through capsid-templated micelle formation and show that the resulting lipoprotein-like cages enhance the cellular delivery of these molecules.
format	article
author	Thomas G. W. Edwardson Stephan Tetter Donald Hilvert
author_facet	Thomas G. W. Edwardson Stephan Tetter Donald Hilvert
author_sort	Thomas G. W. Edwardson
title	Two-tier supramolecular encapsulation of small molecules in a protein cage
title_short	Two-tier supramolecular encapsulation of small molecules in a protein cage
title_full	Two-tier supramolecular encapsulation of small molecules in a protein cage
title_fullStr	Two-tier supramolecular encapsulation of small molecules in a protein cage
title_full_unstemmed	Two-tier supramolecular encapsulation of small molecules in a protein cage
title_sort	two-tier supramolecular encapsulation of small molecules in a protein cage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e746860bb4984ecabeb4e17acef42687
work_keys_str_mv	AT thomasgwedwardson twotiersupramolecularencapsulationofsmallmoleculesinaproteincage AT stephantetter twotiersupramolecularencapsulationofsmallmoleculesinaproteincage AT donaldhilvert twotiersupramolecularencapsulationofsmallmoleculesinaproteincage
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Two-tier supramolecular encapsulation of small molecules in a protein cage

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