Ultrasound-enhanced electrospinning

Abstract Electrospinning is commonly used to produce polymeric nanofibers. Potential applications for such fibers include novel drug delivery systems, tissue engineering scaffolds, and filters. Electrospinning, however, has shortcomings such as needle clogging and limited ability to control the fibe...

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Autores principales:	Heikki J. Nieminen, Ivo Laidmäe, Ari Salmi, Timo Rauhala, Tor Paulin, Jyrki Heinämäki, Edward Hæggström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7497c92868d40ae849fcb325b5b617d
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spelling	oai:doaj.org-article:e7497c92868d40ae849fcb325b5b617d2021-12-02T15:07:51ZUltrasound-enhanced electrospinning10.1038/s41598-018-22124-z2045-2322https://doaj.org/article/e7497c92868d40ae849fcb325b5b617d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22124-zhttps://doaj.org/toc/2045-2322Abstract Electrospinning is commonly used to produce polymeric nanofibers. Potential applications for such fibers include novel drug delivery systems, tissue engineering scaffolds, and filters. Electrospinning, however, has shortcomings such as needle clogging and limited ability to control the fiber-properties in a non-chemical manner. This study reports on an orifice-less technique that employs high-intensity focused ultrasound, i.e. ultrasound-enhanced electrospinning. Ultrasound bursts were used to generate a liquid protrusion with a Taylor cone from the surface of a polymer solution of polyethylene oxide. When the polymer was charged with a high negative voltage, nanofibers jetted off from the tip of the protrusion landed on an electrically grounded target held at a constant distance from the tip. Controlling the ultrasound characteristics permitted physical modification of the nanofiber topography at will without using supplemental chemical intervention. Possible applications of tailor-made fibers generated by ultrasound-enhanced electrospinning include pharmaceutical controlled-release applications and biomedical scaffolds with spatial gradients in fiber thickness and mechanical properties.Heikki J. NieminenIvo LaidmäeAri SalmiTimo RauhalaTor PaulinJyrki HeinämäkiEdward HæggströmNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heikki J. Nieminen Ivo Laidmäe Ari Salmi Timo Rauhala Tor Paulin Jyrki Heinämäki Edward Hæggström Ultrasound-enhanced electrospinning
description	Abstract Electrospinning is commonly used to produce polymeric nanofibers. Potential applications for such fibers include novel drug delivery systems, tissue engineering scaffolds, and filters. Electrospinning, however, has shortcomings such as needle clogging and limited ability to control the fiber-properties in a non-chemical manner. This study reports on an orifice-less technique that employs high-intensity focused ultrasound, i.e. ultrasound-enhanced electrospinning. Ultrasound bursts were used to generate a liquid protrusion with a Taylor cone from the surface of a polymer solution of polyethylene oxide. When the polymer was charged with a high negative voltage, nanofibers jetted off from the tip of the protrusion landed on an electrically grounded target held at a constant distance from the tip. Controlling the ultrasound characteristics permitted physical modification of the nanofiber topography at will without using supplemental chemical intervention. Possible applications of tailor-made fibers generated by ultrasound-enhanced electrospinning include pharmaceutical controlled-release applications and biomedical scaffolds with spatial gradients in fiber thickness and mechanical properties.
format	article
author	Heikki J. Nieminen Ivo Laidmäe Ari Salmi Timo Rauhala Tor Paulin Jyrki Heinämäki Edward Hæggström
author_facet	Heikki J. Nieminen Ivo Laidmäe Ari Salmi Timo Rauhala Tor Paulin Jyrki Heinämäki Edward Hæggström
author_sort	Heikki J. Nieminen
title	Ultrasound-enhanced electrospinning
title_short	Ultrasound-enhanced electrospinning
title_full	Ultrasound-enhanced electrospinning
title_fullStr	Ultrasound-enhanced electrospinning
title_full_unstemmed	Ultrasound-enhanced electrospinning
title_sort	ultrasound-enhanced electrospinning
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e7497c92868d40ae849fcb325b5b617d
work_keys_str_mv	AT heikkijnieminen ultrasoundenhancedelectrospinning AT ivolaidmae ultrasoundenhancedelectrospinning AT arisalmi ultrasoundenhancedelectrospinning AT timorauhala ultrasoundenhancedelectrospinning AT torpaulin ultrasoundenhancedelectrospinning AT jyrkiheinamaki ultrasoundenhancedelectrospinning AT edwardhæggstrom ultrasoundenhancedelectrospinning
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Ultrasound-enhanced electrospinning

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