Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci

Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci

ABSTRACT Streptococcus pneumoniae (or pneumococcus) is a highly prevalent human pathogen. Toll-like receptors (TLRs) function as immune sensors that can trigger host defenses against this bacterium. Defects in TLR-activated signaling pathways, including deficiency in the adaptor protein myeloid diff...

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Bibliographic Details
Main Authors: Agata Famà, Angelina Midiri, Giuseppe Mancuso, Carmelo Biondo, Germana Lentini, Roberta Galbo, Maria Miriam Giardina, Giuseppe Valerio De Gaetano, Letizia Romeo, Giuseppe Teti, Concetta Beninati
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Streptococcus pneumoniae
neutrophils
chemokines
interleukin-12
cytokines
innate immunity
Microbiology
QR1-502
Online Access:https://doaj.org/article/e74b5fe5626a402aa73773157b57416c
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