CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma

Circular RNAs (circRNAs) are usually enriched in neural tissues, yet about 80% circRNAs have lower expression in gliomas relative to normal brains, highlighting the importance of circRNAs as tumor suppressors. However, the clinical impact as well as the pathways regulated by the tumor-suppressive ci...

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Autores principales:	Xue Kong, Ruiting Xu, Wei Wang, Minghui Zeng, Yuan Li, Mengyu Lin, Wenchao Zhou, Xianming Fu, Haibo Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circRNA hsa_circ-0114014 GBM miRNA miR-1281 PDXP Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e74e85108e7a4d9d9e65473ae6735d8d
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spelling	oai:doaj.org-article:e74e85108e7a4d9d9e65473ae6735d8d2021-12-01T13:25:06ZCircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma2296-889X10.3389/fmolb.2021.743417https://doaj.org/article/e74e85108e7a4d9d9e65473ae6735d8d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.743417/fullhttps://doaj.org/toc/2296-889XCircular RNAs (circRNAs) are usually enriched in neural tissues, yet about 80% circRNAs have lower expression in gliomas relative to normal brains, highlighting the importance of circRNAs as tumor suppressors. However, the clinical impact as well as the pathways regulated by the tumor-suppressive circRNAs remain largely unknown in glioblastoma (GBM). Through bioinformatic analysis followed by experimental validation, we found that hsa_circ_0114014 (circLRRC7) was dramatically down-regulated in GBM when compared with normal brain tissues (p < 0.0001). GBM patients with a lower circLRRC7 expression had poorer progression-free survival (PFS, p < 0.05) and overall survival (OS, p < 0.05). Analyses of the predicted target miRNAs of circLRRC7 in CSCD and CRI databases, in combination with the miRNA expression data in GBMs and normal brains from GSE database, revealed miR-1281 as a potential downstream target of circLRRC7. Subsequently, the target genes of hsa-mir-1281 were predicted by TargetScan, miRDB and miRNATAR databases. Intersection analysis and correlation test indicated that PDXP was a potential target of miR-1281. In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment.Xue KongXue KongXue KongXue KongRuiting XuWei WangWei WangMinghui ZengYuan LiMengyu LinWenchao ZhouXianming FuXianming FuXianming FuHaibo WuHaibo WuFrontiers Media S.A.articlecircRNAhsa_circ-0114014GBMmiRNAmiR-1281PDXPBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA hsa_circ-0114014 GBM miRNA miR-1281 PDXP Biology (General) QH301-705.5
spellingShingle	circRNA hsa_circ-0114014 GBM miRNA miR-1281 PDXP Biology (General) QH301-705.5 Xue Kong Xue Kong Xue Kong Xue Kong Ruiting Xu Wei Wang Wei Wang Minghui Zeng Yuan Li Mengyu Lin Wenchao Zhou Xianming Fu Xianming Fu Xianming Fu Haibo Wu Haibo Wu CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma
description	Circular RNAs (circRNAs) are usually enriched in neural tissues, yet about 80% circRNAs have lower expression in gliomas relative to normal brains, highlighting the importance of circRNAs as tumor suppressors. However, the clinical impact as well as the pathways regulated by the tumor-suppressive circRNAs remain largely unknown in glioblastoma (GBM). Through bioinformatic analysis followed by experimental validation, we found that hsa_circ_0114014 (circLRRC7) was dramatically down-regulated in GBM when compared with normal brain tissues (p < 0.0001). GBM patients with a lower circLRRC7 expression had poorer progression-free survival (PFS, p < 0.05) and overall survival (OS, p < 0.05). Analyses of the predicted target miRNAs of circLRRC7 in CSCD and CRI databases, in combination with the miRNA expression data in GBMs and normal brains from GSE database, revealed miR-1281 as a potential downstream target of circLRRC7. Subsequently, the target genes of hsa-mir-1281 were predicted by TargetScan, miRDB and miRNATAR databases. Intersection analysis and correlation test indicated that PDXP was a potential target of miR-1281. In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment.
format	article
author	Xue Kong Xue Kong Xue Kong Xue Kong Ruiting Xu Wei Wang Wei Wang Minghui Zeng Yuan Li Mengyu Lin Wenchao Zhou Xianming Fu Xianming Fu Xianming Fu Haibo Wu Haibo Wu
author_facet	Xue Kong Xue Kong Xue Kong Xue Kong Ruiting Xu Wei Wang Wei Wang Minghui Zeng Yuan Li Mengyu Lin Wenchao Zhou Xianming Fu Xianming Fu Xianming Fu Haibo Wu Haibo Wu
author_sort	Xue Kong
title	CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma
title_short	CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma
title_full	CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma
title_fullStr	CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma
title_full_unstemmed	CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma
title_sort	circularlrrc7 is a potential tumor suppressor associated with mir-1281 and pdxp expression in glioblastoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e74e85108e7a4d9d9e65473ae6735d8d
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CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma

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