Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiqui...

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Autores principales:	Anmol Sharma, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur Grewal, Agnieszka Najda, Małgorzata Kawecka-Radomska, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. del-Daim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer ubiquitination ubiquitin-proteasome system deubiquitination ubiquitin inhibitors Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e74f7df8c33d48aa9c759e1e249f9b75
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spelling	oai:doaj.org-article:e74f7df8c33d48aa9c759e1e249f9b752021-11-11T17:23:34ZPharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling10.3390/ijms2221119711422-00671661-6596https://doaj.org/article/e74f7df8c33d48aa9c759e1e249f9b752021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11971https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiquitinating enzymes (E1, E2, E3) and the proteasome. Therefore, aberrant expression in these enzymes results in an altered biological process, including transduction signaling for cell death and survival, resulting in cancer. In this review, an overview of profuse enzymes involved as a pro-oncogenic or progressive growth factor in tumors with their downstream signaling pathways has been discussed. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling. Various in vitro, in vivo studies demonstrating the involvement of ubiquitin-proteasome systems in varied types of cancers and the downstream signaling pathways involved are also discussed in the current review. Several inhibitors of E1, E2, E3, deubiquitinase enzymes and proteasome have been applied for treating cancer. Some of these drugs have exhibited successful outcomes in in vivo studies on different cancer types, so clinical trials are going on for these inhibitors. This review mainly focuses on certain ubiquitin-proteasome enzymes involved in developing cancers and certain enzymes that can be targeted to treat cancer.Anmol SharmaHeena KhanThakur Gurjeet SinghAmarjot Kaur GrewalAgnieszka NajdaMałgorzata Kawecka-RadomskaMohamed KamelAhmed E. AltyarMohamed M. del-DaimMDPI AGarticlecancerubiquitinationubiquitin-proteasome systemdeubiquitinationubiquitin inhibitorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11971, p 11971 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer ubiquitination ubiquitin-proteasome system deubiquitination ubiquitin inhibitors Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cancer ubiquitination ubiquitin-proteasome system deubiquitination ubiquitin inhibitors Biology (General) QH301-705.5 Chemistry QD1-999 Anmol Sharma Heena Khan Thakur Gurjeet Singh Amarjot Kaur Grewal Agnieszka Najda Małgorzata Kawecka-Radomska Mohamed Kamel Ahmed E. Altyar Mohamed M. del-Daim Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
description	The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiquitinating enzymes (E1, E2, E3) and the proteasome. Therefore, aberrant expression in these enzymes results in an altered biological process, including transduction signaling for cell death and survival, resulting in cancer. In this review, an overview of profuse enzymes involved as a pro-oncogenic or progressive growth factor in tumors with their downstream signaling pathways has been discussed. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling. Various in vitro, in vivo studies demonstrating the involvement of ubiquitin-proteasome systems in varied types of cancers and the downstream signaling pathways involved are also discussed in the current review. Several inhibitors of E1, E2, E3, deubiquitinase enzymes and proteasome have been applied for treating cancer. Some of these drugs have exhibited successful outcomes in in vivo studies on different cancer types, so clinical trials are going on for these inhibitors. This review mainly focuses on certain ubiquitin-proteasome enzymes involved in developing cancers and certain enzymes that can be targeted to treat cancer.
format	article
author	Anmol Sharma Heena Khan Thakur Gurjeet Singh Amarjot Kaur Grewal Agnieszka Najda Małgorzata Kawecka-Radomska Mohamed Kamel Ahmed E. Altyar Mohamed M. del-Daim
author_facet	Anmol Sharma Heena Khan Thakur Gurjeet Singh Amarjot Kaur Grewal Agnieszka Najda Małgorzata Kawecka-Radomska Mohamed Kamel Ahmed E. Altyar Mohamed M. del-Daim
author_sort	Anmol Sharma
title	Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
title_short	Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
title_full	Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
title_fullStr	Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
title_full_unstemmed	Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
title_sort	pharmacological modulation of ubiquitin-proteasome pathways in oncogenic signaling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e74f7df8c33d48aa9c759e1e249f9b75
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Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

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