Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified gh...

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Autores principales:	Yuki Shiimura, Shoichiro Horita, Akie Hamamoto, Hidetsugu Asada, Kunio Hirata, Misuzu Tanaka, Kenji Mori, Tomoko Uemura, Takuya Kobayashi, So Iwata, Masayasu Kojima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e7526d5cb5754366b7a2d14fcf34c3e1
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spelling	oai:doaj.org-article:e7526d5cb5754366b7a2d14fcf34c3e12021-12-02T18:01:15ZStructure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode10.1038/s41467-020-17554-12041-1723https://doaj.org/article/e7526d5cb5754366b7a2d14fcf34c3e12020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17554-1https://doaj.org/toc/2041-1723Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified ghrelin.Yuki ShiimuraShoichiro HoritaAkie HamamotoHidetsugu AsadaKunio HirataMisuzu TanakaKenji MoriTomoko UemuraTakuya KobayashiSo IwataMasayasu KojimaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Shiimura Shoichiro Horita Akie Hamamoto Hidetsugu Asada Kunio Hirata Misuzu Tanaka Kenji Mori Tomoko Uemura Takuya Kobayashi So Iwata Masayasu Kojima Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
description	Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a possible mechanism of activation by acyl-modified ghrelin.
format	article
author	Yuki Shiimura Shoichiro Horita Akie Hamamoto Hidetsugu Asada Kunio Hirata Misuzu Tanaka Kenji Mori Tomoko Uemura Takuya Kobayashi So Iwata Masayasu Kojima
author_facet	Yuki Shiimura Shoichiro Horita Akie Hamamoto Hidetsugu Asada Kunio Hirata Misuzu Tanaka Kenji Mori Tomoko Uemura Takuya Kobayashi So Iwata Masayasu Kojima
author_sort	Yuki Shiimura
title	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_short	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_full	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_fullStr	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_full_unstemmed	Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
title_sort	structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e7526d5cb5754366b7a2d14fcf34c3e1
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Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

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