Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population

Kayo Nakamura1*, Masao Ota2*, Akira Meguro1, et al1Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Departmentof Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, JapanBackground: To investigate whether the GPDS1 locus, a p...

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Autores principales:	Kayo Nakamura, Masao Ota, Akira Meguro, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e7579ee288e44738ad812e2f360b5f81
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spelling	oai:doaj.org-article:e7579ee288e44738ad812e2f360b5f812021-12-02T03:19:13ZAssociation of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population1177-54671177-5483https://doaj.org/article/e7579ee288e44738ad812e2f360b5f812009-04-01T00:00:00Zhttp://www.dovepress.com/association-of-microsatellite-polymorphisms-of-the-gpds1-locus-with-no-a3018https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kayo Nakamura1, Masao Ota2, Akira Meguro1, et al1Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Departmentof Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, JapanBackground: To investigate whether the GPDS1 locus, a potential causative locus of pigment-dispersion syndrome, is associated with normal-tension glaucoma (NTG) in Japanese patients. Materials and methods: We used polymerase chain reaction amplification with sequencespecific primers to analyze 20 polymorphic microsatellite markers in and around the GPDS1 locus with an automated DNA analyzer and automated fragment detection by fluorescent-based technology. The DNA samples used for these analyses were obtained from ethnicity- and gendermatched patients, including 141 Japanese patients with NTG and 101 healthy controls. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement.Results: One allele of D7S2462 exhibited a frequency that was significantly decreased in NTG cases compared to controls (P = 0.0013, Pc = 0.019, OR = 0.48, 95% CI = 0.30&ndash;0.75). Alleles at another six microsatellite loci were positively or negatively associated with NTG, but these associations did not retain statistical significance after Bonferroni correction (P&nbsp;&lt; 0.05, Pc&nbsp;&gt; 0.05).Conclusion: Our study showed a significant association between the GPDS1 locus and NTG, suggesting that there may be some genetic risk factor(s) in the development of NTG.Keywords: microsatellite, normal tension glaucoma, glaucoma-related pigment dispersion syndrome, GPDS1, DPP6 Kayo NakamuraMasao OtaAkira Meguroet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 307-312 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kayo Nakamura Masao Ota Akira Meguro et al Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population
description	Kayo Nakamura1, Masao Ota2, Akira Meguro1, et al1Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Departmentof Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, JapanBackground: To investigate whether the GPDS1 locus, a potential causative locus of pigment-dispersion syndrome, is associated with normal-tension glaucoma (NTG) in Japanese patients. Materials and methods: We used polymerase chain reaction amplification with sequencespecific primers to analyze 20 polymorphic microsatellite markers in and around the GPDS1 locus with an automated DNA analyzer and automated fragment detection by fluorescent-based technology. The DNA samples used for these analyses were obtained from ethnicity- and gendermatched patients, including 141 Japanese patients with NTG and 101 healthy controls. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement.Results: One allele of D7S2462 exhibited a frequency that was significantly decreased in NTG cases compared to controls (P = 0.0013, Pc = 0.019, OR = 0.48, 95% CI = 0.30&ndash;0.75). Alleles at another six microsatellite loci were positively or negatively associated with NTG, but these associations did not retain statistical significance after Bonferroni correction (P&nbsp;&lt; 0.05, Pc&nbsp;&gt; 0.05).Conclusion: Our study showed a significant association between the GPDS1 locus and NTG, suggesting that there may be some genetic risk factor(s) in the development of NTG.Keywords: microsatellite, normal tension glaucoma, glaucoma-related pigment dispersion syndrome, GPDS1, DPP6
format	article
author	Kayo Nakamura Masao Ota Akira Meguro et al
author_facet	Kayo Nakamura Masao Ota Akira Meguro et al
author_sort	Kayo Nakamura
title	Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population
title_short	Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population
title_full	Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population
title_fullStr	Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population
title_full_unstemmed	Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population
title_sort	association of microsatellite polymorphisms of the gpds1 locus with normal tension glaucoma in the japanese population
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/e7579ee288e44738ad812e2f360b5f81
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Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population

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