PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway

Abstract Parthanatos is a newly discovered form of PARP-1-dependent programmed cell death. It has been reported to play an important role in several cancer or tumour cells; however, few studies have been performed in normal cells. Cadmium is a highly toxic pollutant and is reported to induce autopha...

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Autores principales:	Tongwang Luo, Yan Yuan, Qi Yu, Gang Liu, Mengfei Long, Kanglei Zhang, Jianchun Bian, Jianhong Gu, Hui Zou, Yi Wang, Jiaqiao Zhu, Xuezhong Liu, Zongping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e757d754e9234495baf77a7f02ab3bc0
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spelling	oai:doaj.org-article:e757d754e9234495baf77a7f02ab3bc02021-12-02T15:05:06ZPARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway10.1038/s41598-017-04555-22045-2322https://doaj.org/article/e757d754e9234495baf77a7f02ab3bc02017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04555-2https://doaj.org/toc/2045-2322Abstract Parthanatos is a newly discovered form of PARP-1-dependent programmed cell death. It has been reported to play an important role in several cancer or tumour cells; however, few studies have been performed in normal cells. Cadmium is a highly toxic pollutant and is reported to induce autophagy and apoptosis in multiple cell types. Although cadmium toxicity induces cell death, the underlying mechanism is not fully understood. Therefore, in this study we aimed to investigate the mechanism of Cadmium -induced cell damage using rat proximal tubular cell line NRK-52E and primary rat proximal tubular (rPT) cells. Our results indicated that parthanatos and the MAPK signalling pathway contribute to Cadmium-induced cell death, and that oxidative stress and mitochondrial damage play key roles in this process. In addition, parthanatos with oxidative stress has a synergistic effect on apoptosis, and JNK1/2 and p38 contribute to parthanatos.Tongwang LuoYan YuanQi YuGang LiuMengfei LongKanglei ZhangJianchun BianJianhong GuHui ZouYi WangJiaqiao ZhuXuezhong LiuZongping LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongwang Luo Yan Yuan Qi Yu Gang Liu Mengfei Long Kanglei Zhang Jianchun Bian Jianhong Gu Hui Zou Yi Wang Jiaqiao Zhu Xuezhong Liu Zongping Liu PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway
description	Abstract Parthanatos is a newly discovered form of PARP-1-dependent programmed cell death. It has been reported to play an important role in several cancer or tumour cells; however, few studies have been performed in normal cells. Cadmium is a highly toxic pollutant and is reported to induce autophagy and apoptosis in multiple cell types. Although cadmium toxicity induces cell death, the underlying mechanism is not fully understood. Therefore, in this study we aimed to investigate the mechanism of Cadmium -induced cell damage using rat proximal tubular cell line NRK-52E and primary rat proximal tubular (rPT) cells. Our results indicated that parthanatos and the MAPK signalling pathway contribute to Cadmium-induced cell death, and that oxidative stress and mitochondrial damage play key roles in this process. In addition, parthanatos with oxidative stress has a synergistic effect on apoptosis, and JNK1/2 and p38 contribute to parthanatos.
format	article
author	Tongwang Luo Yan Yuan Qi Yu Gang Liu Mengfei Long Kanglei Zhang Jianchun Bian Jianhong Gu Hui Zou Yi Wang Jiaqiao Zhu Xuezhong Liu Zongping Liu
author_facet	Tongwang Luo Yan Yuan Qi Yu Gang Liu Mengfei Long Kanglei Zhang Jianchun Bian Jianhong Gu Hui Zou Yi Wang Jiaqiao Zhu Xuezhong Liu Zongping Liu
author_sort	Tongwang Luo
title	PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway
title_short	PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway
title_full	PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway
title_fullStr	PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway
title_full_unstemmed	PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway
title_sort	parp-1 overexpression contributes to cadmium-induced death in rat proximal tubular cells via parthanatos and the mapk signalling pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e757d754e9234495baf77a7f02ab3bc0
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PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway

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