Dilute pilocarpine test for diagnosis of Adie’s tonic pupil

Abstract We have compared the diagnostic ability of different concentrations of 0.125% and 0.0625% dilute pilocarpine for detecting denervation supersensitivity in unilateral Adie’s tonic pupil. This retrospective, observational, case–control study involved 117 subjects, consisting of 56 patients wi...

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Autores principales:	Yung-Ju Yoo, Jeong-Min Hwang, Hee Kyung Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e757fdd0bca84155a77c3f16a65c1772
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spelling	oai:doaj.org-article:e757fdd0bca84155a77c3f16a65c17722021-12-02T15:54:50ZDilute pilocarpine test for diagnosis of Adie’s tonic pupil10.1038/s41598-021-89148-w2045-2322https://doaj.org/article/e757fdd0bca84155a77c3f16a65c17722021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89148-whttps://doaj.org/toc/2045-2322Abstract We have compared the diagnostic ability of different concentrations of 0.125% and 0.0625% dilute pilocarpine for detecting denervation supersensitivity in unilateral Adie’s tonic pupil. This retrospective, observational, case–control study involved 117 subjects, consisting of 56 patients with unilateral Adie’s tonic pupil and 61 controls with other causes of unilateral dilated pupils. Subjects underwent the dilute pilocarpine test with one of the two concentrations, 0.125% or 0.0625%. Pupillary light reflex was recorded with a dynamic pupillometer at baseline and at 30–40 min after instilling one of the two concentrations of dilute pilocarpine. Diagnostic accuracy of two different concentrations of the dilute pilocarpine test, 0.125% group versus 0.0625% group, were compared by area under the receiver operating characteristic curve (AUC). Diagnostic ability of the dilute pilocarpine test for detecting denervation supersensitivity in unilateral Adie’s tonic pupil was significantly better in the 0.0625% group than in the 0.125% group (AUC = 0.954 vs. 0.840, respectively, P = 0.047). In the 0.0625% group, the change in maximal pupil diameter of ≥ 0.5 mm after topical pilocarpine instillation showed 100% sensitivity and 82.8% specificity for detecting Adie’s tonic pupil. This study confirmed that pupillary constriction with 0.0625% pilocarpine is better than 0.125% pilocarpine for detecting denervation supersensitivity in Adie’s tonic pupil. Digital pupillometry is a reliable method for assessing denervation supersensitivity in Adie's tonic pupil.Yung-Ju YooJeong-Min HwangHee Kyung YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yung-Ju Yoo Jeong-Min Hwang Hee Kyung Yang Dilute pilocarpine test for diagnosis of Adie’s tonic pupil
description	Abstract We have compared the diagnostic ability of different concentrations of 0.125% and 0.0625% dilute pilocarpine for detecting denervation supersensitivity in unilateral Adie’s tonic pupil. This retrospective, observational, case–control study involved 117 subjects, consisting of 56 patients with unilateral Adie’s tonic pupil and 61 controls with other causes of unilateral dilated pupils. Subjects underwent the dilute pilocarpine test with one of the two concentrations, 0.125% or 0.0625%. Pupillary light reflex was recorded with a dynamic pupillometer at baseline and at 30–40 min after instilling one of the two concentrations of dilute pilocarpine. Diagnostic accuracy of two different concentrations of the dilute pilocarpine test, 0.125% group versus 0.0625% group, were compared by area under the receiver operating characteristic curve (AUC). Diagnostic ability of the dilute pilocarpine test for detecting denervation supersensitivity in unilateral Adie’s tonic pupil was significantly better in the 0.0625% group than in the 0.125% group (AUC = 0.954 vs. 0.840, respectively, P = 0.047). In the 0.0625% group, the change in maximal pupil diameter of ≥ 0.5 mm after topical pilocarpine instillation showed 100% sensitivity and 82.8% specificity for detecting Adie’s tonic pupil. This study confirmed that pupillary constriction with 0.0625% pilocarpine is better than 0.125% pilocarpine for detecting denervation supersensitivity in Adie’s tonic pupil. Digital pupillometry is a reliable method for assessing denervation supersensitivity in Adie's tonic pupil.
format	article
author	Yung-Ju Yoo Jeong-Min Hwang Hee Kyung Yang
author_facet	Yung-Ju Yoo Jeong-Min Hwang Hee Kyung Yang
author_sort	Yung-Ju Yoo
title	Dilute pilocarpine test for diagnosis of Adie’s tonic pupil
title_short	Dilute pilocarpine test for diagnosis of Adie’s tonic pupil
title_full	Dilute pilocarpine test for diagnosis of Adie’s tonic pupil
title_fullStr	Dilute pilocarpine test for diagnosis of Adie’s tonic pupil
title_full_unstemmed	Dilute pilocarpine test for diagnosis of Adie’s tonic pupil
title_sort	dilute pilocarpine test for diagnosis of adie’s tonic pupil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e757fdd0bca84155a77c3f16a65c1772
work_keys_str_mv	AT yungjuyoo dilutepilocarpinetestfordiagnosisofadiestonicpupil AT jeongminhwang dilutepilocarpinetestfordiagnosisofadiestonicpupil AT heekyungyang dilutepilocarpinetestfordiagnosisofadiestonicpupil
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Dilute pilocarpine test for diagnosis of Adie’s tonic pupil

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