The effects of Curcuma longa and curcumin on reproductive systems

Objective. Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-in...

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Autores principales:	Mohebbati R., Anaeigoudari A., Khazdair M.R.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	curcuma longa curcumin therapeutic effects reproductive system Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/e759519f312444ee832e20bf3483d103
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spelling	oai:doaj.org-article:e759519f312444ee832e20bf3483d1032021-12-02T15:29:47ZThe effects of Curcuma longa and curcumin on reproductive systems1336-032910.1515/enr-2017-0024https://doaj.org/article/e759519f312444ee832e20bf3483d1032017-10-01T00:00:00Zhttps://doi.org/10.1515/enr-2017-0024https://doaj.org/toc/1336-0329Objective. Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-inflammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an effort on a detailed literature survey concentrated on the protective effects of C. longa and curcumin on the reproductive organs activity. Methods. The databases such as, PubMed, Web of Science, Google Scholar, Scopus, and Iran- Medex, were considered. The search terms were “testis” or “ovary” and “Curcuma longa”, “curcumin”, “antioxidant effect”, “anti-inflammatory effect” and “anti-cancer effect”. Results. C. longa and curcumin inhibited the production of the tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) and increased the caspases (3, 8 and 9) activities in HL-60 prostate cancer. Furthermore, C. longa and curcumin suppressed the vascular endothelial growth factor (VEGF), phosphorylated signal transducers and activators of the transcription 3 (STAT) and matrix metalloproteinase-9 (MMP-9) in ovarian cancer cell line. Conclusion. C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. C. longa and curcumin have a protective effect on the reproductive organs activity such as, anti-inflammatory, anti-apoptotic, and antioxidant effects in normal cells but showed pro-apoptotic effects in the malignant cells. Therefore, different effects of C. longa and curcumin are dependent on the doses and the type of cells used in various models studied.Mohebbati R.Anaeigoudari A.Khazdair M.R.Sciendoarticlecurcuma longacurcumintherapeutic effectsreproductive systemDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 51, Iss 4, Pp 220-228 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcuma longa curcumin therapeutic effects reproductive system Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	curcuma longa curcumin therapeutic effects reproductive system Diseases of the endocrine glands. Clinical endocrinology RC648-665 Mohebbati R. Anaeigoudari A. Khazdair M.R. The effects of Curcuma longa and curcumin on reproductive systems
description	Objective. Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-inflammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an effort on a detailed literature survey concentrated on the protective effects of C. longa and curcumin on the reproductive organs activity. Methods. The databases such as, PubMed, Web of Science, Google Scholar, Scopus, and Iran- Medex, were considered. The search terms were “testis” or “ovary” and “Curcuma longa”, “curcumin”, “antioxidant effect”, “anti-inflammatory effect” and “anti-cancer effect”. Results. C. longa and curcumin inhibited the production of the tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) and increased the caspases (3, 8 and 9) activities in HL-60 prostate cancer. Furthermore, C. longa and curcumin suppressed the vascular endothelial growth factor (VEGF), phosphorylated signal transducers and activators of the transcription 3 (STAT) and matrix metalloproteinase-9 (MMP-9) in ovarian cancer cell line. Conclusion. C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. C. longa and curcumin have a protective effect on the reproductive organs activity such as, anti-inflammatory, anti-apoptotic, and antioxidant effects in normal cells but showed pro-apoptotic effects in the malignant cells. Therefore, different effects of C. longa and curcumin are dependent on the doses and the type of cells used in various models studied.
format	article
author	Mohebbati R. Anaeigoudari A. Khazdair M.R.
author_facet	Mohebbati R. Anaeigoudari A. Khazdair M.R.
author_sort	Mohebbati R.
title	The effects of Curcuma longa and curcumin on reproductive systems
title_short	The effects of Curcuma longa and curcumin on reproductive systems
title_full	The effects of Curcuma longa and curcumin on reproductive systems
title_fullStr	The effects of Curcuma longa and curcumin on reproductive systems
title_full_unstemmed	The effects of Curcuma longa and curcumin on reproductive systems
title_sort	effects of curcuma longa and curcumin on reproductive systems
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/e759519f312444ee832e20bf3483d103
work_keys_str_mv	AT mohebbatir theeffectsofcurcumalongaandcurcuminonreproductivesystems AT anaeigoudaria theeffectsofcurcumalongaandcurcuminonreproductivesystems AT khazdairmr theeffectsofcurcumalongaandcurcuminonreproductivesystems AT mohebbatir effectsofcurcumalongaandcurcuminonreproductivesystems AT anaeigoudaria effectsofcurcumalongaandcurcuminonreproductivesystems AT khazdairmr effectsofcurcumalongaandcurcuminonreproductivesystems
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The effects of Curcuma longa and curcumin on reproductive systems

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