Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction

Abstract The prognostic nutritional index (PNI) has been applied in acute myocardial infarction (AMI) recently.However, the application of PNI in AMI needs verification. This was a prospective cohort study. Patients diagnosed with AMI were enrolled. PNI was calculated as (serum albumin (SA in g/L)) ...

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Autores principales:	Yisong Cheng, Hong Li, Dongze Li, Lianjing Liang, Yu Jia, Liqun Zou, Fanghui Li, Xingyu Zhu, Hong Qian, Na He, Zhi Zeng, Rui Zeng, Yu Cao, Zhi Wan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e75cca817fa742cfac3189397bdb4a50
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spelling	oai:doaj.org-article:e75cca817fa742cfac3189397bdb4a502021-12-02T15:09:28ZPrognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction10.1038/s41598-019-51044-92045-2322https://doaj.org/article/e75cca817fa742cfac3189397bdb4a502019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51044-9https://doaj.org/toc/2045-2322Abstract The prognostic nutritional index (PNI) has been applied in acute myocardial infarction (AMI) recently.However, the application of PNI in AMI needs verification. This was a prospective cohort study. Patients diagnosed with AMI were enrolled. PNI was calculated as (serum albumin (SA in g/L)) + (5 × total lymphocyte count (TLC) × 109/L). Modified PNI (mPNI) was analyzed by logistic regression analysis to reset the proportion of SA and TLC. The primary outcome was all-cause death. A total of 598 patients were enrolled; 73 patients died during follow-up. The coefficient of SA and TLC in the mPNI formula was approximately 2:1. The area under the receiver operating characteristic curve of SA, TLC, PNI, mPNI and GRACE in predicting death for patients with AMI was 0.718, 0.540, 0.636, 0.721 and 0.825, respectively. Net reclassification improvement (NRI) between PNI and mPNI was 0.230 (p < 0.001). Integrated discrimination improvement (IDI) was 0.042 (p = 0.001). Decision curve analysis revealed that mPNI had better prognostic value for patients with AMI than PNI; however, it was not superior to SA. Thus, PNI may not a reliable prognostic predictor of AMI; after resetting the formula, the value of PNI in predicting prognosis of AMI is almost entirely due to SA.Yisong ChengHong LiDongze LiLianjing LiangYu JiaLiqun ZouFanghui LiXingyu ZhuHong QianNa HeZhi ZengRui ZengYu CaoZhi WanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yisong Cheng Hong Li Dongze Li Lianjing Liang Yu Jia Liqun Zou Fanghui Li Xingyu Zhu Hong Qian Na He Zhi Zeng Rui Zeng Yu Cao Zhi Wan Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
description	Abstract The prognostic nutritional index (PNI) has been applied in acute myocardial infarction (AMI) recently.However, the application of PNI in AMI needs verification. This was a prospective cohort study. Patients diagnosed with AMI were enrolled. PNI was calculated as (serum albumin (SA in g/L)) + (5 × total lymphocyte count (TLC) × 109/L). Modified PNI (mPNI) was analyzed by logistic regression analysis to reset the proportion of SA and TLC. The primary outcome was all-cause death. A total of 598 patients were enrolled; 73 patients died during follow-up. The coefficient of SA and TLC in the mPNI formula was approximately 2:1. The area under the receiver operating characteristic curve of SA, TLC, PNI, mPNI and GRACE in predicting death for patients with AMI was 0.718, 0.540, 0.636, 0.721 and 0.825, respectively. Net reclassification improvement (NRI) between PNI and mPNI was 0.230 (p < 0.001). Integrated discrimination improvement (IDI) was 0.042 (p = 0.001). Decision curve analysis revealed that mPNI had better prognostic value for patients with AMI than PNI; however, it was not superior to SA. Thus, PNI may not a reliable prognostic predictor of AMI; after resetting the formula, the value of PNI in predicting prognosis of AMI is almost entirely due to SA.
format	article
author	Yisong Cheng Hong Li Dongze Li Lianjing Liang Yu Jia Liqun Zou Fanghui Li Xingyu Zhu Hong Qian Na He Zhi Zeng Rui Zeng Yu Cao Zhi Wan
author_facet	Yisong Cheng Hong Li Dongze Li Lianjing Liang Yu Jia Liqun Zou Fanghui Li Xingyu Zhu Hong Qian Na He Zhi Zeng Rui Zeng Yu Cao Zhi Wan
author_sort	Yisong Cheng
title	Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
title_short	Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
title_full	Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
title_fullStr	Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
title_full_unstemmed	Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
title_sort	prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e75cca817fa742cfac3189397bdb4a50
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Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction

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