Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy

Danial Mohabati,1,2 Thomas J van Rijssen,1 Elon HC van Dijk,1 Gregorius PM Luyten,1 Tom O Missotten,3 Carel B Hoyng,4 Suzanne Yzer,3 Camiel JF Boon1,5 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institut...

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Autores principales:	Mohabati D, van Rijssen TJ, van Dijk EHC, Luyten GPM, Missotten TO, Hoyng CB, Yzer S, Boon CJF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Chronic central serous chorioretinopathy long-term outcome severity treatment Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e75d2c3072144145aa3b6f0371a8d773
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spelling	oai:doaj.org-article:e75d2c3072144145aa3b6f0371a8d7732021-12-02T07:59:43ZClinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy1177-5483https://doaj.org/article/e75d2c3072144145aa3b6f0371a8d7732018-06-01T00:00:00Zhttps://www.dovepress.com/clinical-characteristics-and-long-term-visual-outcome-of-severe-phenot-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Danial Mohabati,1,2 Thomas J van Rijssen,1 Elon HC van Dijk,1 Gregorius PM Luyten,1 Tom O Missotten,3 Carel B Hoyng,4 Suzanne Yzer,3 Camiel JF Boon1,5 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands; 4Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 5Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Purpose: The aim of this study was to investigate disease onset and disease progression in patients with severe chronic central serous chorioretinopathy (cCSC). Patients and methods: The medical records of 143 cCSC patients (199 eyes) were reviewed. All cases had visual complaints for >6 months and showed signs of a severe disease phenotype on optical coherence tomography (OCT) and fluorescein angiography (FA). Clinical presentation at onset was evaluated, together with disease progression on multimodal imaging and final treatment outcome. Results: Twenty-eight cases (14%) had a documented history of an acute episode of CSC, whereas 145 cases (73%) showed pre-existing features of chronicity already at first presentation. The first clinical presentation could not be evaluated in 13% of cases. Best-corrected visual acuity (BCVA) was 70 ± 18 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters at onset and 70 ± 22 ETDRS letters at final visit (p = 0.770). Among all studied cases, 173 eyes (87%) were treated, which resulted in complete resolution of subretinal fluid (SRF) in 76% of eyes at final visit. In eyes with fluorescein angiographic follow-up, the area of diffuse atrophic retinal pigment epithelium (RPE) abnormalities (diffuse atrophic RPE alterations [DARA]) had increased significantly in 43 eyes (68%) at final visit. Conclusion: CSC encompasses a clinical spectrum that includes a range of severe phenotypes, in which retinal abnormalities tend to be progressive. Nevertheless, the long-term visual acuity may remain fairly stable with treatment. Few patients with severe chronic CSC have a history of acute CSC, which could indicate that there may be pathogenetic differences between these 2 CSC variants. Keywords: chronic central serous chorioretinopathy, long-term outcome, severity, treatment, photodynamic therapy, posterior cystoid retinal degenerationMohabati Dvan Rijssen TJvan Dijk EHCLuyten GPMMissotten TOHoyng CBYzer SBoon CJFDove Medical PressarticleChronic central serous chorioretinopathylong-term outcomeseveritytreatmentOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1061-1070 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic central serous chorioretinopathy long-term outcome severity treatment Ophthalmology RE1-994
spellingShingle	Chronic central serous chorioretinopathy long-term outcome severity treatment Ophthalmology RE1-994 Mohabati D van Rijssen TJ van Dijk EHC Luyten GPM Missotten TO Hoyng CB Yzer S Boon CJF Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
description	Danial Mohabati,1,2 Thomas J van Rijssen,1 Elon HC van Dijk,1 Gregorius PM Luyten,1 Tom O Missotten,3 Carel B Hoyng,4 Suzanne Yzer,3 Camiel JF Boon1,5 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands; 4Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 5Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Purpose: The aim of this study was to investigate disease onset and disease progression in patients with severe chronic central serous chorioretinopathy (cCSC). Patients and methods: The medical records of 143 cCSC patients (199 eyes) were reviewed. All cases had visual complaints for >6 months and showed signs of a severe disease phenotype on optical coherence tomography (OCT) and fluorescein angiography (FA). Clinical presentation at onset was evaluated, together with disease progression on multimodal imaging and final treatment outcome. Results: Twenty-eight cases (14%) had a documented history of an acute episode of CSC, whereas 145 cases (73%) showed pre-existing features of chronicity already at first presentation. The first clinical presentation could not be evaluated in 13% of cases. Best-corrected visual acuity (BCVA) was 70 ± 18 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters at onset and 70 ± 22 ETDRS letters at final visit (p = 0.770). Among all studied cases, 173 eyes (87%) were treated, which resulted in complete resolution of subretinal fluid (SRF) in 76% of eyes at final visit. In eyes with fluorescein angiographic follow-up, the area of diffuse atrophic retinal pigment epithelium (RPE) abnormalities (diffuse atrophic RPE alterations [DARA]) had increased significantly in 43 eyes (68%) at final visit. Conclusion: CSC encompasses a clinical spectrum that includes a range of severe phenotypes, in which retinal abnormalities tend to be progressive. Nevertheless, the long-term visual acuity may remain fairly stable with treatment. Few patients with severe chronic CSC have a history of acute CSC, which could indicate that there may be pathogenetic differences between these 2 CSC variants. Keywords: chronic central serous chorioretinopathy, long-term outcome, severity, treatment, photodynamic therapy, posterior cystoid retinal degeneration
format	article
author	Mohabati D van Rijssen TJ van Dijk EHC Luyten GPM Missotten TO Hoyng CB Yzer S Boon CJF
author_facet	Mohabati D van Rijssen TJ van Dijk EHC Luyten GPM Missotten TO Hoyng CB Yzer S Boon CJF
author_sort	Mohabati D
title	Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
title_short	Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
title_full	Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
title_fullStr	Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
title_full_unstemmed	Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
title_sort	clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e75d2c3072144145aa3b6f0371a8d773
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Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy

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