An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites

Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with guanylyl cyclase α (GCα), a cGMP synthesizing...

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Autores principales:	Yuanyuan Jiang, Jun Wei, Huiting Cui, Chuanyuan Liu, Yuan Zhi, ZhengZheng Jiang, Zhenkui Li, Shaoneng Li, Zhenke Yang, Xu Wang, Pengge Qian, Cui Zhang, Chuanqi Zhong, Xin-zhuan Su, Jing Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e75e23b5db604657a447b8b5f749ea12
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spelling	oai:doaj.org-article:e75e23b5db604657a447b8b5f749ea122021-12-02T15:39:07ZAn intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites10.1038/s41467-020-15479-32041-1723https://doaj.org/article/e75e23b5db604657a447b8b5f749ea122020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15479-3https://doaj.org/toc/2041-1723Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with guanylyl cyclase α (GCα), a cGMP synthesizing enzyme in gametocytes.Yuanyuan JiangJun WeiHuiting CuiChuanyuan LiuYuan ZhiZhengZheng JiangZhenkui LiShaoneng LiZhenke YangXu WangPengge QianCui ZhangChuanqi ZhongXin-zhuan SuJing YuanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanyuan Jiang Jun Wei Huiting Cui Chuanyuan Liu Yuan Zhi ZhengZheng Jiang Zhenkui Li Shaoneng Li Zhenke Yang Xu Wang Pengge Qian Cui Zhang Chuanqi Zhong Xin-zhuan Su Jing Yuan An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites
description	Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with guanylyl cyclase α (GCα), a cGMP synthesizing enzyme in gametocytes.
format	article
author	Yuanyuan Jiang Jun Wei Huiting Cui Chuanyuan Liu Yuan Zhi ZhengZheng Jiang Zhenkui Li Shaoneng Li Zhenke Yang Xu Wang Pengge Qian Cui Zhang Chuanqi Zhong Xin-zhuan Su Jing Yuan
author_facet	Yuanyuan Jiang Jun Wei Huiting Cui Chuanyuan Liu Yuan Zhi ZhengZheng Jiang Zhenkui Li Shaoneng Li Zhenke Yang Xu Wang Pengge Qian Cui Zhang Chuanqi Zhong Xin-zhuan Su Jing Yuan
author_sort	Yuanyuan Jiang
title	An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites
title_short	An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites
title_full	An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites
title_fullStr	An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites
title_full_unstemmed	An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites
title_sort	intracellular membrane protein gep1 regulates xanthurenic acid induced gametogenesis of malaria parasites
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e75e23b5db604657a447b8b5f749ea12
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An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites

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