Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study

Background: There is a large amount of evidence that anti-angiogenic drugs are effective safe. However, few studies have evaluated the specific effects of anti-angiogenic drugs on myocardial enzyme injury biomarkers: aspartate aminotransferase (AST), lactic dehydrogenase (LDH), creatine kinase (CK)...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qi Zheng, Hanzhou Wang, Wei Hou, Ying Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	anti-angiogenic drugs cancer AST LDH CK CK-MB Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e760e4e626e14368a55662b5ce4f0672
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e760e4e626e14368a55662b5ce4f0672
record_format	dspace
spelling	oai:doaj.org-article:e760e4e626e14368a55662b5ce4f06722021-12-02T09:05:19ZUse of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study2297-055X10.3389/fcvm.2021.755191https://doaj.org/article/e760e4e626e14368a55662b5ce4f06722021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.755191/fullhttps://doaj.org/toc/2297-055XBackground: There is a large amount of evidence that anti-angiogenic drugs are effective safe. However, few studies have evaluated the specific effects of anti-angiogenic drugs on myocardial enzyme injury biomarkers: aspartate aminotransferase (AST), lactic dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether anti-angiogenic drugs serum AST, LDH, CK, and CK-MB activities of cancer patients treated with anti-angiogenic drugs.Methods: This study retrospectively analyzed 81 cancer patients. Patients who had used anti-angiogenic drugs were selected. Serum AST, LDH, CK, and CK-MB activities were measured before and after treatment with anti-angiogenic drugs for 3 weeks.Results: A total of 16 cancer types were analyzed. The distribution of the cancer types in the patients was mainly concentrated in lung, gastric, and colorectal cancers. The anti-angiogenic treatment markedly increased AST, LDH, CK, and CK-MB activities by 32.51, 7.29, 31.25, and 55.56%, respectively in serum.Conclusions: Our findings suggest that patients, who had used anti-angiogenic drugs were likely to have elevated AST, LDH, and CK, indicators of myocardial muscle injury. Use of anti-angiogenic drugs should not be assumed to be completely safe and without any cardiovascular risks.Qi ZhengHanzhou WangWei HouYing ZhangFrontiers Media S.A.articleanti-angiogenic drugscancerASTLDHCKCK-MBDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-angiogenic drugs cancer AST LDH CK CK-MB Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	anti-angiogenic drugs cancer AST LDH CK CK-MB Diseases of the circulatory (Cardiovascular) system RC666-701 Qi Zheng Hanzhou Wang Wei Hou Ying Zhang Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study
description	Background: There is a large amount of evidence that anti-angiogenic drugs are effective safe. However, few studies have evaluated the specific effects of anti-angiogenic drugs on myocardial enzyme injury biomarkers: aspartate aminotransferase (AST), lactic dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether anti-angiogenic drugs serum AST, LDH, CK, and CK-MB activities of cancer patients treated with anti-angiogenic drugs.Methods: This study retrospectively analyzed 81 cancer patients. Patients who had used anti-angiogenic drugs were selected. Serum AST, LDH, CK, and CK-MB activities were measured before and after treatment with anti-angiogenic drugs for 3 weeks.Results: A total of 16 cancer types were analyzed. The distribution of the cancer types in the patients was mainly concentrated in lung, gastric, and colorectal cancers. The anti-angiogenic treatment markedly increased AST, LDH, CK, and CK-MB activities by 32.51, 7.29, 31.25, and 55.56%, respectively in serum.Conclusions: Our findings suggest that patients, who had used anti-angiogenic drugs were likely to have elevated AST, LDH, and CK, indicators of myocardial muscle injury. Use of anti-angiogenic drugs should not be assumed to be completely safe and without any cardiovascular risks.
format	article
author	Qi Zheng Hanzhou Wang Wei Hou Ying Zhang
author_facet	Qi Zheng Hanzhou Wang Wei Hou Ying Zhang
author_sort	Qi Zheng
title	Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study
title_short	Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study
title_full	Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study
title_fullStr	Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study
title_full_unstemmed	Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study
title_sort	use of anti-angiogenic drugs potentially associated with an increase on serum ast, ldh, ck, and ck-mb activities in patients with cancer: a retrospective study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e760e4e626e14368a55662b5ce4f0672
work_keys_str_mv	AT qizheng useofantiangiogenicdrugspotentiallyassociatedwithanincreaseonserumastldhckandckmbactivitiesinpatientswithcanceraretrospectivestudy AT hanzhouwang useofantiangiogenicdrugspotentiallyassociatedwithanincreaseonserumastldhckandckmbactivitiesinpatientswithcanceraretrospectivestudy AT weihou useofantiangiogenicdrugspotentiallyassociatedwithanincreaseonserumastldhckandckmbactivitiesinpatientswithcanceraretrospectivestudy AT yingzhang useofantiangiogenicdrugspotentiallyassociatedwithanincreaseonserumastldhckandckmbactivitiesinpatientswithcanceraretrospectivestudy
_version_	1718398277588615168

Use of Anti-angiogenic Drugs Potentially Associated With an Increase on Serum AST, LDH, CK, and CK-MB Activities in Patients With Cancer: A Retrospective Study

Ejemplares similares