Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.

A novel method is described for mapping dynamic cerebral blood flow autoregulation to assess autoregulatory efficiency throughout the brain, using magnetic resonance imaging (MRI). Global abnormalities in autoregulation occur in clinical conditions, including stroke and head injury, and are of progn...

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Autores principales:	Mark A Horsfield, José L Jara, Nazia P Saeed, Ronney B Panerai, Thompson G Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e764003307484cbbbf2fe6fba9c0ad62
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spelling	oai:doaj.org-article:e764003307484cbbbf2fe6fba9c0ad622021-11-18T07:47:28ZRegional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.1932-620310.1371/journal.pone.0062588https://doaj.org/article/e764003307484cbbbf2fe6fba9c0ad622013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23638121/?tool=EBIhttps://doaj.org/toc/1932-6203A novel method is described for mapping dynamic cerebral blood flow autoregulation to assess autoregulatory efficiency throughout the brain, using magnetic resonance imaging (MRI). Global abnormalities in autoregulation occur in clinical conditions, including stroke and head injury, and are of prognostic significance. However, there is limited information about regional variations. A gradient-echo echo-planar pulse sequence was used to scan the brains of healthy subjects at a rate of 1 scan/second during a transient decrease in arterial blood pressure provoked by a sudden release of pressure in bilateral inflated thigh cuffs. The signal decrease and subsequent recovery were analyzed to provide an index of autoregulatory efficiency (MRARI). MRI time-series were successfully acquired and analyzed in eleven subjects. Autoregulatory efficiency was not uniform throughout the brain: white matter exhibited faster recovery than gray (MRARI = 0.702 vs. 0.672, p = 0.009) and the cerebral cortex exhibited faster recovery than the cerebellum (MRARI = 0.669 vs. 0.645, p = 0.016). However, there was no evidence for differences between different cortical regions. Differences in autoregulatory efficiency between white matter, gray matter and the cerebellum may be a result of differences in vessel density and vasodilation. The techniques described may have practical importance in detecting regional changes in autoregulation consequent to disease.Mark A HorsfieldJosé L JaraNazia P SaeedRonney B PaneraiThompson G RobinsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62588 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mark A Horsfield José L Jara Nazia P Saeed Ronney B Panerai Thompson G Robinson Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
description	A novel method is described for mapping dynamic cerebral blood flow autoregulation to assess autoregulatory efficiency throughout the brain, using magnetic resonance imaging (MRI). Global abnormalities in autoregulation occur in clinical conditions, including stroke and head injury, and are of prognostic significance. However, there is limited information about regional variations. A gradient-echo echo-planar pulse sequence was used to scan the brains of healthy subjects at a rate of 1 scan/second during a transient decrease in arterial blood pressure provoked by a sudden release of pressure in bilateral inflated thigh cuffs. The signal decrease and subsequent recovery were analyzed to provide an index of autoregulatory efficiency (MRARI). MRI time-series were successfully acquired and analyzed in eleven subjects. Autoregulatory efficiency was not uniform throughout the brain: white matter exhibited faster recovery than gray (MRARI = 0.702 vs. 0.672, p = 0.009) and the cerebral cortex exhibited faster recovery than the cerebellum (MRARI = 0.669 vs. 0.645, p = 0.016). However, there was no evidence for differences between different cortical regions. Differences in autoregulatory efficiency between white matter, gray matter and the cerebellum may be a result of differences in vessel density and vasodilation. The techniques described may have practical importance in detecting regional changes in autoregulation consequent to disease.
format	article
author	Mark A Horsfield José L Jara Nazia P Saeed Ronney B Panerai Thompson G Robinson
author_facet	Mark A Horsfield José L Jara Nazia P Saeed Ronney B Panerai Thompson G Robinson
author_sort	Mark A Horsfield
title	Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
title_short	Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
title_full	Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
title_fullStr	Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
title_full_unstemmed	Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
title_sort	regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e764003307484cbbbf2fe6fba9c0ad62
work_keys_str_mv	AT markahorsfield regionaldifferencesindynamiccerebralautoregulationinthehealthybrainassessedbymagneticresonanceimaging AT joseljara regionaldifferencesindynamiccerebralautoregulationinthehealthybrainassessedbymagneticresonanceimaging AT naziapsaeed regionaldifferencesindynamiccerebralautoregulationinthehealthybrainassessedbymagneticresonanceimaging AT ronneybpanerai regionaldifferencesindynamiccerebralautoregulationinthehealthybrainassessedbymagneticresonanceimaging AT thompsongrobinson regionaldifferencesindynamiccerebralautoregulationinthehealthybrainassessedbymagneticresonanceimaging
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Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging.

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