Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.

When mammalian spermatozoa become capacitated they acquire, among other activities, chemotactic responsiveness and the ability to exhibit occasional events of hyperactivated motility--a vigorous motility type with large amplitudes of head displacement. Although a number of roles have been proposed f...

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Autores principales:	Leah Armon, Michael Eisenbach
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e768fdd292c144fa876450c4693de587
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spelling	oai:doaj.org-article:e768fdd292c144fa876450c4693de5872021-11-18T07:32:51ZBehavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.1932-620310.1371/journal.pone.0028359https://doaj.org/article/e768fdd292c144fa876450c4693de5872011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22163296/?tool=EBIhttps://doaj.org/toc/1932-6203When mammalian spermatozoa become capacitated they acquire, among other activities, chemotactic responsiveness and the ability to exhibit occasional events of hyperactivated motility--a vigorous motility type with large amplitudes of head displacement. Although a number of roles have been proposed for this type of motility, its function is still obscure. Here we provide evidence suggesting that hyperactivation is part of the chemotactic response. By analyzing tracks of spermatozoa swimming in a spatial chemoattractant gradient we demonstrate that, in such a gradient, the level of hyperactivation events is significantly lower than in proper controls. This suggests that upon sensing an increase in the chemoattractant concentration capacitated cells repress their hyperactivation events and thus maintain their course of swimming toward the chemoattractant. Furthermore, in response to a temporal concentration jump achieved by photorelease of the chemoattractant progesterone from its caged form, the responsive cells exhibited a delayed turn, often accompanied by hyperactivation events or an even more intense response in the form of flagellar arrest. This study suggests that the function of hyperactivation is to cause a rather sharp turn during the chemotactic response of capacitated cells so as to assist them to reorient according to the chemoattractant gradient. On the basis of these results a model for the behavior of spermatozoa responding to a spatial chemoattractant gradient is proposed.Leah ArmonMichael EisenbachPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28359 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leah Armon Michael Eisenbach Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
description	When mammalian spermatozoa become capacitated they acquire, among other activities, chemotactic responsiveness and the ability to exhibit occasional events of hyperactivated motility--a vigorous motility type with large amplitudes of head displacement. Although a number of roles have been proposed for this type of motility, its function is still obscure. Here we provide evidence suggesting that hyperactivation is part of the chemotactic response. By analyzing tracks of spermatozoa swimming in a spatial chemoattractant gradient we demonstrate that, in such a gradient, the level of hyperactivation events is significantly lower than in proper controls. This suggests that upon sensing an increase in the chemoattractant concentration capacitated cells repress their hyperactivation events and thus maintain their course of swimming toward the chemoattractant. Furthermore, in response to a temporal concentration jump achieved by photorelease of the chemoattractant progesterone from its caged form, the responsive cells exhibited a delayed turn, often accompanied by hyperactivation events or an even more intense response in the form of flagellar arrest. This study suggests that the function of hyperactivation is to cause a rather sharp turn during the chemotactic response of capacitated cells so as to assist them to reorient according to the chemoattractant gradient. On the basis of these results a model for the behavior of spermatozoa responding to a spatial chemoattractant gradient is proposed.
format	article
author	Leah Armon Michael Eisenbach
author_facet	Leah Armon Michael Eisenbach
author_sort	Leah Armon
title	Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
title_short	Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
title_full	Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
title_fullStr	Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
title_full_unstemmed	Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
title_sort	behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e768fdd292c144fa876450c4693de587
work_keys_str_mv	AT leaharmon behavioralmechanismduringhumanspermchemotaxisinvolvementofhyperactivation AT michaeleisenbach behavioralmechanismduringhumanspermchemotaxisinvolvementofhyperactivation
_version_	1718423321092030464

Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation.

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